激动素 ,99%

中文名：激动素 ,99%
英文名：Kinetin
CAS号：525-79-1
分子式：C10H9N5O
分子量：215.21
Beilstein号：21703
EC号： 208-382-2
MDL号： MFCD00075757
PubChem编号：24896228
属性
敏感性 否
密度 1.4890
荧光 否
IC50 否
pK Values 否
描述
别名 激动素 ;6-糠氨基嘌呤;6-Furfurylaminopurine,N6-Furfuryladenine
产品介绍 溶于水，易溶于稀盐酸或氢氧化钠碱液；微溶于甲醇和乙醇。
生化机理
Description:
IC50 Value: N/A
Kinetin (N6-furfuryladenine) belongs to a group of plant growth hormones involved in cell division, differentiation and other physiological processes. Kinetin is one of the widely used components in numerous skin care cosmetics and cosmeceuticals, such as Valeant products kinerase. Recently, kinetin has the potential to be a treatment for the human splicing disease familial dysautonomia.
in vitro: Kinetin-induced cell death reflected by the morphological changes of nuclei including their invagination, volume increase, chromatin condensation and degradation as well as formation of micronuclei showed by AO/EB and 4,6-diamidino-2-phenylindol staining was accompanied by changes including increase in conductivity of cell electrolytes secreted to culture media, decrease in the number of the G1- and G2-phase cells and appearance of fraction of hypoploid cells as the effect of DNA degradation without ladder formation [1]. The plant cytokinin kinetin dramatically increases exon 20 inclusion in RNA isolated from cultured FD cells [3].
in vivo: Subjects received 23.5 mg/Kg/d for 28 d. An increase in WT IKBKAP mRNA expression in leukocytes was noted after 8 d in six of eight individuals; after 28 d, the mean increase compared with baseline was significant (p = 0.002) [2].
Toxicity: On mice with leukaemia P388, kinetin has no effect on the tumour growth, and it appears to be toxic at the dose of 25 mg/kg [4].
Clinical trial: N/A

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