- $2536
- Alomone
- 以色列
- AK-535
- 2025年07月14日
- 见官方网站
- 见说明书
- 见官方网站
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- 详细信息
- 技术资料
- 免疫原：
见官方网站
- 亚型：
见官方网站
- 形态：
液体或冻干粉
- 保存条件：
-20°C
- 克隆性：
多克隆
- 标记物：
见官方网站
- 适应物种：
见官方网站
- 保质期：
6个月
- 抗原来源：
见说明书
- 目录编号：
AK-535
- 级别：
高
- 库存：
大量
- 供应商：
上海信裕生物科技有限公司
- 宿主：
见说明书
- 应用范围：
见官方网站
- 浓度：
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- 靶点：
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- 抗体英文名：
Mitochondrial Ion Channel Antibody Explorer Kit
- 抗体名：
Mitochondrial Ion Channel Antibody Explorer Kit
- 规格：
31 Vials
Mitochondrial Ion Channel Antibody Explorer Kit
A Screening Package of Mitochondrial Ion Channel Antibodies Economically PricedCat #: AK-535
31 Vials
Alomone Labs is pleased to offer the Mitochondrial Ion Channel Antibody Explorer Kit (#AK-535). The Explorer Kit contains mitochondrial ion channel antibodies, ideal for screening purposes.
- Compounds
- Scientific Background
Mitochondria are the main energy producing organelles of the cell. They are comprised of an outer membrane (OMM), an inner membrane (IMM), a space between them and a matrix enclosed within the IMM. Many of the ion channels found in mitochondria are vital for energy supply by the mitochondria for the rest of the cell. Channels are located both in the OMM and IMM.
The most abundant and well-studied OMM ion channel is the voltage-dependent anion channel (VDAC). This channel has a β-barrel structure composed of 19 β-strands and an NH2-terminal α-helix. In addition to various anions this channel conducts substantial flows of Ca2+, ATP and superoxidase. This channel is presumed to be highly regulated and to serve as the main gateway for cellular-mitochondrial “cross-talk”.
Another ion channel observed in the OMM is the Inward rectifying voltage dependent potassium selective ion channel (Kir). The activity of this channel is regulated by cAMP and osmolarity and is blocked by cesium cations. Interestingly, other classical potassium channel inhibitors do not block the channel.
The IMM contains a large number of potassium channels with different structural and functional properties including Big-conductance, intermediate and small-conductance calcium-activated potassium channels. In addition, there are KV1.3 voltage gated potassium channels which are hypothesized to be similar to plasma membrane KV1.3 channels in structure but their functional properties remain unclear. Other IMM ion channels are pH-sensitive potassium channels and various calcium, potassium and non-selective cation channels1.
References
- Szabo, I. and Zorrati, M. (2014) Physiol. Rev. 94, 519.
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