- $656
- Alomone
- 以色列
- ESB-10201
- 2025年07月14日
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- 见说明书
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
见官方网站
- 亚型：
见官方网站
- 形态：
液体或冻干粉
- 保存条件：
-20°C
- 克隆性：
多克隆
- 标记物：
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- 适应物种：
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- 保质期：
6个月
- 抗原来源：
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- 目录编号：
ESB-10201
- 级别：
高
- 库存：
大量
- 供应商：
上海信裕生物科技有限公司
- 宿主：
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- 应用范围：
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- 浓度：
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- 抗体英文名：
ASIC3 Channel Basic Research Pack
- 抗体名：
ASIC3 Channel Basic Research Pack
- 规格：
8 Vials
ASIC3 Channel Basic Research Pack
All You Need for ASIC3 Channel ResearchCat #: ESB-10201
8 Vials
Alomone Labs is pleased to offer the ASIC3 Channel Basic Research Pack (#ESB-201). The Research Pack contains all you need for ASIC3 channel research: Antibodies recognizing different domains of the channel, membrane lysates expressing ASIC3 channel- your ideal control for western blot analysis and specific ASIC3 channel activator and blocker, all in one economical package!
- Compounds
- Scientific Background
- Related Products
ASIC3 is a member of a family of Na+ channels that are activated by external protons. The family includes another three members ASIC1, ASIC2 and ASIC4. The ASICs are in fact part of a larger superfamily termed degenerin/epithelial Na+ channels (DEG/ENaC) and share with it the same basic characteristics: two transmembrane spanning domains, a large extracellular domain and short intracellular N- and C- termini.
Several lines of evidence indicate that ASIC3 may function as a pain sensor. First, it is specifically located in dorsal root ganglia (DRG) neurons and in nociceptors that are involved in pain detection and transmission. In addition, in conditions such as inflammation and cardiac ischemia that include tissue acidosis and thus pain, ASIC3 currents have been detected. Finally, ASIC3 deficient mice display altered sensitivity to high intensity pain produced by heat or acid.
Interestingly, while in rats ASIC3 is expressed almost exclusively in DRG neurons, in humans its expression is more widespread suggesting a more extensive role in human nociception.
References
- Kellenberger, S. and Schild, L. (2002) Physiol. Rev. 82, 735.
- Chen, C. C. et al. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 8992.
- Price, M.P. et al. (2001) Neuron 32, 1071.
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in the management of pain. Using the TRPV1 channel as an example, here we describe some basic biophysical approaches used to study the properties of ion channels involved in pain and in analgesia.
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