- ¥1170 - 24640
- 江蓝纯
- P00164
- 2025年07月10日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
99
- 供应商：
江蓝纯
- 规格：
10ug/50ug/500ug/1mg
| 规格： | 10ug | 产品价格： | ¥1170.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ¥3520.0 |
| 规格： | 500ug | 产品价格： | ¥17240.0 |
| 规格： | 1mg | 产品价格： | ¥24640.0 |
| Known as | Microtubule-associated protein tau; MAPTL; Neurofibrillary tangle protein; MTBT1; Paired helical filament-tau; TAU and MAPT; |
|---|---|
| Derived from | E.coli |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| Shipping | The product is shipped at ambient temperature. |
| Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months |
| Reconstitution | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Endotoxin | Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test. |
| Background | Tau proteins are proteins which contain four Tau/MAP repeats. They promote microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. The tau proteins are the product of alternative splicing from a single gene that in humans is designated MAPT. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. |
Recombinant Human Microtubule-Associated Protein Tau-F is produced by our E.coli expression system and the target gene encoding Met1-Leu441 is expressed.
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文献和实验of microtubule-associated proteins. Tau is strongly expressed in neurons, localized in the axon and is essential for neuronal architecture, plasticity and network. In animal models, overexpression of mutated Tau proteins is often used to induce a Tau pathology
Tau Phosphorylation Both In Vitro and in Cells
Tau was originally isolated from brain microtubules and shown to be a microtubule-associated protein (MAP) that promoted tubulin polymerization (1 ). It is largely confined to axons, where it is the major MAP. It promotes microtubule nucleation
Cell-Based Assays for Regulators of Tau Biology
, which may ultimately lead to translational outcomes for AD. In particular, the intracellular microtubule-associated protein tau that accumulates in AD is found in normal cells. Manipulating these cells may allow us to address basic questions about tau biology
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