- $410
- 丹麦BioPorto Diagnostics A/S
- 丹麦
- MON R-5
- 2025年07月09日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4-8ºC without exposure to light. No precautions necessary during handling.
- 保质期：
12个月
- 库存：
大量
- 供应商：
上海信裕生物科技有限公司
- 抗体英文名：
Anti-Urokinase plasminogen activator receptor
- 规格：
200ug/1mg
Anti-Urokinase plasminogen activator receptor (human, uPAR)
- Cat. No.
- MON R-5
- Product name
- Anti-Urokinase plasminogen activator receptor (human, uPAR)
- Description
-
Mouse monoclonal antibody
- Specificity
-
MON R-5 is specific for human uPAR. No cross-reactivity is observed with murine uPAR, human uPA, human tPA or human PAI-1 when tested by ELISA and immunoblotting. MON R-5 reacts with domain 1 when tested by immunoprecipitation of proteolytic fragments of recombinant suPAR.
- Immunogen
-
Native human uPAR
- Application
- ELISA, IHC
- Species reactivity (positive)
- Human
- Species reactivity (negative)
- Not determined
- Subclass
-
IgG1
- Gene ID
- 5329
- Clone number
- R-5
- Epitope
-
MON R-5 reacts with an epitope on domain 1 and differs from that of MON R-3
- Content
-
Available in 200 µL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.
- Purification
- Protein-A purified
- Form
- Liquid
- Solvent
- 0.01 M phosphate buffer, pH 7.4, containing 0.14 M NaCl and 15 mM sodium azide
- Storage
- 4-8ºC without exposure to light. No precautions necessary during handling.
- Target
-
Urokinase plasminogen activator receptor (uPAR), also known as CD87, is a glycolipid anchored cell surface protein consisting of three homologous domains. It binds uPA with high affinity and enhances and localizes uPA catalyzed plasminogen activation, and thereby plays a key role in cancer invasion and in several tissue remodelling processes. In addition uPAR also binds to vitronectin and may thereby have biological functions independent of its role in uPA mediated proteolysis. Elevated levels of uPAR are associated with poor prognosis in many types of cancer.
- Other information
- This product is not for further manufacture.
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文献和实验in an attempt to retard invasion and migration. Of these methods, RNA interference (RNAi) holds great therapeutic potential. RNAi technology is now being used to target specific molecules for use as potential anti-cancer agents. RNAi-mediated silencing
RFLP Molecular Analysis of the Urokinase-Type Plasminogen Activator Gene
proenzyme forms of matrix metalloproteases. Thus, uPA is a central molecule in pericellular proteolysis (1 -1 ). uPA (as well as other factors of the plasminogen activator system, the cell surface-associated uPA receptor [uPAR], and the plasminogen
as the Northern blot (2 ). Both are, then, often key elements in establishing the identity of nucleic acids of interest. Northern blot analysis was used by us as a tool in order to answer the question whether or not the nuclear transcripitional apparatus of human
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