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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
见官方网站
- 亚型:
见官方网站
- 形态:
冻干粉或液体
- 保存条件:
-20ºC
- 克隆性:
多克隆
- 标记物:
见官方网站
- 适应物种:
见官方网站
- 保质期:
1年
- 抗原来源:
见官方网站
- 目录编号:
ABS 002-096
- 级别:
见官方网站
- 库存:
30
- 供应商:
上海泽叶生物科技有限公司
- 宿主:
Human
- 应用范围:
ELISA, IHC
- 浓度:
1 mg/ml
- 靶点:
见官方网站
- 抗体英文名:
Anti-Complement component C1s (human, pro- and activated enzyme)
- 抗体名:
Anti-Complement component C1s (human, pro- and activated enzyme)
- 规格:
200ug
Anti-Complement component C1s (human, pro- and activated enzyme)
Bioporto是一家体外诊断公司,专业为临床和科研提供一系列诊断试剂盒和抗体。其领先的产品组合包括了用于急性肾功能损伤诊断用的NGAL以及其它疾病检测用抗体。官方网站:www.bioporto.com
- Cat. No.
- ABS 002-096
- Product name
- Anti-Complement component C1s (human, pro- and activated enzyme)
- Description
-
Mouse monoclonal antibody
- Specificity
-
ABS 002-09 is specific for C1s proenzyme and activated free C1s
- Immunogen
-
C1s proenzyme purified from human plasma
- Application
- ELISA, IHC
- Species reactivity (positive)
- Human
- Species reactivity (negative)
- Not determined
- Subclass
-
IgG1/k
- Gene ID
- 716
- Clone number
- 9
- Epitope
-
Epitope differs from that of ABS 002-49
- Content
-
Available in 200 µL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.
- Purification
- Protein-A purified
- Form
- Liquid
- Solvent
- 0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
- Storage
- 4-8ºC without exposure to light. No precautions necessary during handling.
- Target
-
C1s proenzyme is a 79.8 kDa glycoprotein produced primarily by hepatocytes but also by other cells. The proenzyme is produced as a single-chain polypeptide of 688 aa. Upon activation the peptide is cleaved between R437 and I438 giving the activated enzyme consisting of two disulfide-linked chains, A chain (52.2 kDa) and B chain (27.7 kDa). The Ca-dependent catalytic subunit of the C1 complex (C1q, C1r, C1s) comprises of two C1s and two C1r molecules and this serine protease tetramer is responsible for the initial steps in the classical complement pathway, cleavage of C4 and C2.
- Application 1
-
ELISA
ABS 002-09 reacts in ELISA when tested with activated C1s enzyme directly coated onto the microtiter well or in sandwich ELISA in combination with a polyclonal antibody in coat.
- Application 2
-
IHC
ABS 002-09 was used in immunohistochemistry

Plasma shows distinct positivity stained with ABS 002-09 on normal rectum tissue.
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文献和实验Expression and Purification Methods for the Production of Recombinant Human Complement Component C2
Human complement component C2 is a critical factor of the classical complement pathway. Here we provide a method for the production of recombinant human C2 (rhC2) protein for research purposes. The human complement component C2 (hC
associates with the recognition protein C1q. The C1 complex circulates in serum as a zymogen and is activated upon binding of C1q to appropriate targets, such as antigen–antibody complexes. This property is used for the purification of C1r and C1s from human
Molecular Analysis of Complement Component C4 Gene Copy Number
Classical, alternative, or lectin pathways may activate the complement system cascade. The classical pathway includes the C4 protein and functions in the prevention of immune complex precipitation and in clearance of immune complexes
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