Anti-Filamentous Hemagglutinin

Anti-Filamentous Hemagglutinin (FHA)

Bioporto是一家体外诊断公司，专业为临床和科研提供一系列诊断试剂盒和抗体。其领先的产品组合包括了用于急性肾功能损伤诊断用的NGAL以及其它疾病检测用抗体。
官方网站：www.bioporto.com

Cat. No.

HYB 352-02B

Product name

Anti-Filamentous Hemagglutinin (FHA)

Description

Mouse monoclonal antibody, biotinlylated

Specificity

FHA from Bordetella pertussis.Cross-reactivity to cerebral microvessels has been reported.

Immunogen

Whole cell pertussis vaccine + FHA.

Application

ELISA

Species reactivity (positive)

Human

Species reactivity (negative)

Not determined

Subclass

IgG1/k

Gene ID

2667059

Clone number

12.6F8

Epitope

Not determined.

Content

50 µL, 1 mg/mL +/- 15%. See Certificate of Analysis for details.

Purification

Protein-A purified

Form

Liquid

Solvent

0.01 M phosphate buffer, pH 7.4, with 0.14 M NaCl and 15 mM sodium azide

Storage

4-8ºC without exposure to light. No precautions necessary during handling.

Target

Filamentous hemagglutinin (FHA) of Bordetella pertussis is a 220 kDa large adhesive surface protein which together with the pertussis toxin (PTx) facilitates attachment of the bacteria to human ciliated cells and macrophages during the course of whooping cough. FHA can recognize and bind the leukocyte-restricted adhesion molecule (CD11b/CD18, Mac-1) suggesting that FHA mimics a natural ligand on endothelial cells for this integrin which enables FHA to competitively interfere with CD18-dependent leukocyte migration to the central nervous system.

Application 1

ELISA
HYB 352-02 was used in ELISA (1).