HYB 320-04 is specific for the non-quinoline sidechain of amodiaquine. HYB 320-04 can be used for quantitation of amodiaquine in human serum or plasma with a detection limit of app. 2 ng/ml. HYB 320-04 reacts with amodiaquine and is able to distinguish from other antimalarial drugs. Cross-reactivity towards desethylchloroquine is app. 1%. Cross-reactivity towards desethylamodiaquine has not been tested.
Immunogen
4-amino-2(diethylaminomethyl)phenol a preparation of a carrier protein
Application
ELISA
Species reactivity (positive)
Not applicable
Species reactivity (negative)
Not applicable
Subclass
IgG2a/k
Clone number
6D10
Epitope
HYB 320-04 is specific for the non-quinoline sidechain of amodiaquine
Content
Available in 200 µL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification
Protein-A purified
Form
Liquid
Solvent
0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target
Amodiaquine is an antimalarial drug with effects very similar to those of chloroquine. Amodiaquine has been widely used to treat malaria. Due to reports of fatal adverse drug reactions, discontinuation or modification of its use has been suggested.
Amodiaquine is a hapten of molecular weight 267.3 g/mol.