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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
江蓝纯
- 规格:
10mM×0.2ml/5mg/25mg
| 规格: | 10mM×0.2ml | 产品价格: | ¥78.0 |
|---|---|---|---|
| 规格: | 5mg | 产品价格: | ¥120.0 |
| 规格: | 25mg | 产品价格: | ¥344.0 |
| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SC0209-25mg | Nilotinib (Bcr-Abl抑制剂) | 25mg | 344.00元 |
化学信息:
| 化学名 | 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide | ![]() |
| 简称 | Nilotinib | |
| 别名 | AMN-107, AMN 107, AMN107, Tasigna, 尼罗替尼 | |
| 中文名 | 尼洛替尼 | |
| 化学式 | C28H22F3N7O | |
| 分子量 | 529.52 | |
| CAS号 | 641571-10-0 | |
| 纯度 | 99.8% | |
| 溶剂/溶解度 | Water <1mg/ml; DMSO 27mg/ml; Ethanol <1mg/ml | |
| 溶液配制 | 5mg加入0.94ml DMSO,或者每5.3mg加入1ml DMSO,配制成10mM溶液。SC0209-10mM用DMSO配制。 |
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文献和实验Fluorescence In Situ Hybridization for BCR-ABL
The BCR-ABL fusion gene arises as a result of a reciprocal translocation between chromosomes 9 and 22, resulting in the so-called Philadelphia (Ph) chromosome (a minute chromosome 22), which is found in 95% of cases of chronic myeloid
The use of oligodeoxynucleotides (ODN) to disrupt gene function has been studied in a variety of in vitro and in vivo systems (1 –14 ). Antigene, antisense, ribozyme, and aptamer nucleic acid molecules have been shown in numerous model
Detection of BCR-ABL Mutations and Resistance to Imatinib Mesylate
The major mechanism of imatinib resistance for patients with chronic myeloid leukemia (CML) is clonal expansion of leukemic cells with mutations in the Bcr-Abl fusion tyrosine kinase that reduce the capacity of imatinib to inhibit kinase
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