北京现货重组小鼠Semaphorin 4D(Sema4D)哪

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名称：北京现货重组小鼠Semaphorin 4D(Sema4D)哪里买
英文名：Recombinant Mouse Semaphorin 4D
规格：10μg|50μg|500μg|1mg
品牌：百奥莱博
编号：JN1282
产地：国产|进口
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Phe24-Met711在C端带有Fc标签。

Semaphorin 4D质量控制：＞95%(还原性SDS-PAGE)

Semaphorin 4D制剂：冻干品

Semaphorin 4D保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

Semaphorin 4D复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于Semaphorin 4D：
SEMA4D is a member of the semaphorin family,contains one Ig-like C2-type domain, one PSI domain and one Sema domain. SEMA4D is strongly expressed in lymphoid tissues, especially in the thymus, as well as in the nervous tissues. However, SEMA4D is expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver. SEMA4D is a cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. SEMA4D is involved in a number of fundamental biological processes such as promoting reorganization of the actin cytoskeleton, the migration of cerebellar granule cells and of endothelial cells and signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Not only these, it plays a role in axonal growth cone guidance in the developing central nervous system. Semaphorin-4D / SEMA4D may play a functional role in the immune system, as well as in the nervous system. It could induce B-cells to aggregate and improves their viability (in vitro). SEMA4D is involved in regulating dendrite and axon branching and morphogenesis and promoting interaction with PLXNB1 mediates activation of RHOA.

北京现货重组小鼠Semaphorin 4D(Sema4D)哪里买正在火爆热销，除此之外，为您推荐下别热销产品：

·重组人透明质酸酶1(Hyaluronidase-1)
编号：JN0839
英文名称：Recombinant Human Hyaluronidase-1
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Phe22-Trp435在C端含有His标签。

Hyaluronidase-1质量控制：＞95%(还原性SDS-PAGE)

Hyaluronidase-1制剂：液体

Hyaluronidase-1保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于Hyaluronidase-1：
Hyaluronidase-1 (HYAL1) is a secreted lysosomal hyaluronidase that belongs to the glycosyl hydrolase 56 family. HYAL1 contains one EGF-like domain and is highly expressed in the liver, kidney, and heart, but it is weakly expressed in the lung, placenta, and skeletal muscle. HYAL1 is thought to be involved in cell proliferation, migration, and differentiation. It may play a role in promoting tumor progression and blocking the TGFB1-enhanced cell growth. Mutations in HYAL1 are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency.


北京现货重组小鼠Semaphorin 4D(Sema4D)哪里买关键词：重组小鼠Semaphorin 4D,重组小鼠Semaphorin 4D蛋白,JN1282,重组小鼠Sema4D,重组Semaphorin 4D


·重组小鼠PD-1(程序化细胞死亡蛋白1)
编号：JN1895
英文名称：Recombinant Mouse Programmed Cell Death Protein 1
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Leu25-Gln167在C端含有His标签。

PD-1质量控制：＞95%(还原性SDS-PAGE)

PD-1制剂：冻干品

PD-1保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

PD-1复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于PD-1：
Programmed Death-1 (PD-1), firstly cloned from mouse T cell hybridoma 2B4.11, is one member of CD28/CTLA-4 superfamily. PD-1 belongs to type I transmembrane protein and acts as an important immunosuppressive molecule. The cytoplamsic tail of PD-1 contains two structural motifs, an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) formed by two tyrosine residues which make the difference in PD-1 signal mediating.Mouse PD-1 is expressed in thymus and shares about 69% aa sequence identity with human PD-1. Recently, programmed death-1 (PD-1) with its ligands, programmed death ligand B7H1 (PD-L1) and B7DC (PD-L2), was found to regulate T-cell activation and tolerance, upon ligand binding, inhibiting T-cell effector functions in an antigen-specific manner.PD-1 gene knocked out mice would induce some autoimmune diseases, which suggests that PD-1 acts as a co-inhibitory molecule actively participating in maintaining peripheral tolerance. Thus, PD-1 may be a useful target for the immunologic therapy of carcinoma,infection,autoimmune diseases as well as organ transplantation.


北京现货重组小鼠Semaphorin 4D(Sema4D)哪里买关键词：重组小鼠Semaphorin 4D,重组小鼠Semaphorin 4D蛋白,JN1282,重组小鼠Sema4D,重组Semaphorin 4D

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