重组小鼠白介素IL-36α(白细胞介素36α)批发

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名称：重组小鼠白介素IL-36α(白细胞介素36α)批发
品牌：百奥莱博
产地：国产|进口
规格：10μg|50μg|500μg|1mg
英文名：Recombinant Mouse Interleukin-36 alpha
编号：JN0389
本品由我们的大肠杆菌表达系统制备，目的基因编码的Arg8-His160表达纯化而来。

IL-36 alpha/IL-36a质量控制：＞95%(还原性SDS-PAGE)。

IL-36 alpha/IL-36a制剂：冻干品

IL-36 alpha/IL-36a保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

IL-36 alpha/IL-36a复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于IL-36 alpha/IL-36a：
Mouse Interleukin-36 alpha(Il-36a)is a member of the IL-1 family.IL¬1α,IL¬1β and IL-18 are potent inflammatory cytokines whose activities are dependent on heterodimeric receptors of the IL-1R superfamily, and which are regulated by soluble antagonists. Il36a is expressed in many cells, including monocytes, B cells, and T cells, immune system and fetal brains. Il36a is a cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. It is a part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. It seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. It Induces the production of proinflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23 in bone marrow-derived dendritic cells (BMDCs). Moreover, it is involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II and can induce the production of IFN-gamma, IL-4 and IL-17 by cultured CD4+ T cells and splenocytes. Il36a may play a role in proinflammatory effects in the lung: induces the expression of CXCL1 and CXCL2 in the lung, and the expression of TNF-alpha, IL-36c, IL-1A, IL-1B, CXCL1 and CXCL2 in isolated splenic CD11c+ alveolar macrophages. It may be involved in T cell maturation by stimulating the surface expression of CD40 and modestly CD80 and CD86 in splenic CD11c+ cells and CD4+ T cell proliferation.

欲了解更多重组小鼠白介素IL-36α(白细胞介素36α)批发的品牌、产地、价格及说明书等产品信息，请致电北京百奥莱博科技有限公司，我们将竭诚为您服务，另外，以下产品正在火爆促销:

·重组小鼠EGF(带His标签)
编号：JN0254
英文名称：Recombinant Mouse epidermal growth factor
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备，目的基因编码的Asn977-Arg1029在C端含有His标签。

EGF质量控制：＞95%(还原性SDS-PAGE)。

EGF制剂：冻干品

EGF保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

EGF复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于EGF：
EGF is a single-pass type I membrane protein,containing 8 LDL-receptor class B repeats and 9 EGF-like domains. EGF results in cellular proliferation, differentiation, and survival.EGF is a low-molecular-weight polypeptide first purified from the mouse submandibular gland, but since then found in many human tissues including submandibular gland, parotid gland. Salivary EGF, which seems also regulated by dietary inorganic iodine, also plays an important physiological role in the maintenance of oro-esophageal and gastric tissue integrity. The biological effects of salivary EGF include healing of oral and gastroesophageal ulcers, inhibition of gastric acid secretion, stimulation of DNA synthesis as well as mucosal protection from intraluminal injurious factors such as gastric acid, bile acids, pepsin, and trypsin and to physical, chemical and bacterial agents.


重组小鼠白介素IL-36α(白细胞介素36α)批发关键词：重组小鼠白细胞介素36α,JN0389,重组白介素IL-36α,重组小鼠白介素IL-36α蛋白


·重组人趋化因子CCL5(RANTES)
编号：JN0293
英文名称：Recombinant Human C-C Motif Chemokine 5
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备，目的基因编码的Ser24-Ser91表达纯化而来。

CCL5/RANTES质量控制：＞95%(还原性SDS-PAGE)。

CCL5/RANTES制剂：冻干品

CCL5/RANTES保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

CCL5/RANTES复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于CCL5/RANTES：
Human Chemokine (C-C Motif) Ligand 5 (CCL5) plays an active role in recruiting leukocytes into inflammatory sites. CCL5 is secreted by many cell types at inflammatory sites and it exerts a wide range of activities through the receptors CCR1, CCR3, CCR4, and CCR5. N-Terminal truncated CCL5/RANTES, Met-RANTES, and amino-oxypentane (AOP)-RANTES exhibit antagonist or partial agonist functions on their receptors. CCL5/RANTES attracts different subtypes of leukocytes into inflamed tissue and intervenes in a wide range of allergic and autoimmune diseases.


重组小鼠白介素IL-36α(白细胞介素36α)批发关键词：重组小鼠白细胞介素36α,JN0389,重组白介素IL-36α,重组小鼠白介素IL-36α蛋白


·重组人半乳糖凝集素14(Galectin-14)
编号：JN0728
英文名称：Recombinant Human Galectin-14
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Met1-Asp139在C端含有His标签。

Galectin-14质量控制：＞95%(还原性SDS-PAGE)

Galectin-14制剂：液体

Galectin-14保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于Galectin-14：
Galectin-14 is a member of the Galectin family of carbohydrate binding proteins. The members of Galectin family contain one or two carbohydrate recognition domains, which can bind β-Galactoside. LGALS14 is expressed intracellularly in placenta and eosinophils, and is released by eosinophils following allergen stimulation. LGALS14 may be involved in the development of allergic inflammation. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.

·重组人微管相关蛋白Tau-D(MAPT)
编号：JN1959
英文名称：Recombinant Human Microtubule-Associated Protein Tau-D
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Gln249-Gln381在C端含有His标签。

MAPT质量控制：＞95%(还原性SDS-PAGE)

MAPT制剂：冻干品

MAPT保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

MAPT复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于MAPT：
Microtubule-Associated Protein TAU is abundantly expressed in neurons of the central nervous system and less commonly expressed elsewhere, but is also expressed at very low levels in CNS astrocytes and oligodendrocytes. Tau interacts with tubulin to stabilize microtubules and promotes tubulin assembly into microtubules. The C-terminus of TAU binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau acts as a linker protein. When tau is defective, and no longer stabilize microtubules properly, it can result in dementias such as Alzheimers disease and other tauopathies.

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