重组人LAIR1(白细胞相关免疫球蛋白样受体1) 分子生物学

特别声明：本产品及我公司所售其他产品均为科研类试剂产品，严禁用于药物、医疗及其他非科研用途。

重组人LAIR1(白细胞相关免疫球蛋白样受体1) 分子生物学试剂的品牌：百奥莱博，是优质的分子生物学试剂产品，用于生化研究，本产品质量好，且极具价格优势，深为用户称道，了解更多重组人LAIR1(白细胞相关免疫球蛋白样受体1)等分子生物学试剂产品请联系我司咨询订购。

名称：重组人LAIR1(白细胞相关免疫球蛋白样受体1) 分子生物学试剂
编号：JN1678
品牌：百奥莱博
规格：10μg|50μg|500μg|1mg
英文名：Recombinant Human Leukocyte-Associated Immunoglobulin-Like Receptor 1
产地：国产|进口
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Gln22-His163在C端含有His标签。

LAIR1质量控制：＞95%(还原性SDS-PAGE)

LAIR1制剂：冻干品

LAIR1保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

LAIR1复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于LAIR1：
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) is a single-pass type I membrane protein. LAIR1 expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells, highly in naive T-cells and B-cells. As an inhibitory receptor, LAIR1 plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. LAIR1 plays inhibitory role independently of SH2-containing phosphatases and modulates cytokine production in CD4+ T-cells. It down-regulates IL2 and IFNG production while inducing secretion of transforming growth factor beta, also down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. LAIR1 inhibits the differentiation of peripheral blood precursors towards dendritic cells. It also restrains proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells.

想要了解更多关于重组人LAIR1(白细胞相关免疫球蛋白样受体1) 分子生物学试剂的价格、品牌、厂家、说明书、促销信息，请和我们联系。此外我公司还销*(代"售")下面的产品：

·重组人CD3ε
编号：JN1555
英文名称：Recombinant Human T-cell surface glycoprotein CD3 epsilon chain
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Asp23-Asp126在C端带有Fc标签。

CD3ε质量控制：＞95%(还原性SDS-PAGE)

CD3ε制剂：冻干品

CD3ε保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

CD3ε复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于CD3ε：
T-Cell Surface Glycoprotein CD3 ε Chain (CD3ε) is a single-pass type I membrane protein. CD3ε contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3ε is a polypeptide encoded by the CD3E gene on chromosome 11 in humans. The T cell receptor-CD3 complex (TCR/CD3 complex) is involved in T-cell development and several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). TCR/CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.


重组人LAIR1(白细胞相关免疫球蛋白样受体1) 分子生物学试剂关键词：重组人LAIR1,JN1678,重组LAIR1,重组人LAIR1蛋白,重组人白细胞相关免疫球蛋白样受体1


·重组人半胱*酸双加氧酶1(CDO1)
编号：JN0863
英文名称：Recombinant Human Cysteine Dioxygenase Type 1
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Asn200在N端含有His标签。

CDO1质量控制：＞95%(还原性SDS-PAGE)

CDO1制剂：液体

CDO1保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于CDO1：
Cysteine Dioxygenase Type 1 (CDO1) is a mammalian non-heme iron enzyme that belongs to the cysteine dioxygenase family. CDO1 is highly expressed in the liver and placenta, and has a low expression in heart, brain and pancreas. CDO1 can also be detected in hepatoblastoma HepG2 cells. CDO1 catalyzes the conversion of L-cysteine to cysteine sulfinic acid by incorporation of dioxygen. CDO1 is a vital regulator of cellular cysteine concentrations and has an essential role in maintaining the hepatic concentration of intracellular free cysteine within a proper narrow range. CDO1 is able to alter intracellular cysteine levels and glutathione levels.


重组人LAIR1(白细胞相关免疫球蛋白样受体1) 分子生物学试剂关键词：重组人LAIR1,JN1678,重组LAIR1,重组人LAIR1蛋白,重组人白细胞相关免疫球蛋白样受体1

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