- ￥3000 - 3999
- Abbiotec
- 美国
- 251895
- 2025年07月15日
- E, WB, IHC
- Rabbit
- H, M, R
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human SOCS-1.
- 亚型：
Rabbit Ig
- 形态：
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 5% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.
- 保存条件：
Store at -20°C.
- 克隆性：
多克隆
- 标记物：
见下方详细说明
- 适应物种：
H, M, R
- 保质期：
1-2年
- 抗原来源：
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human SOCS-1.
- 目录编号：
251895
- 级别：
超纯
- 库存：
大量
- 供应商：
Abbiotec
- 宿主：
Rabbit
- 应用范围：
E, WB, IHC
- 浓度：
见详细说明信息
- 靶点：
SOCS-1
- 抗体英文名：
SOCS-1 Antibody
- 抗体名：
SOCS-1 Antibody
- 规格：
0.1 mg
SOCS-1 Antibody产品详细介绍：
| 产品名称： | SOCS-1 Antibody |
| 说明书： | 【点击查看详细说明及参考图片】 |
| 货号： | 251895 |
| 规格： | 0.1 mg |
| 产品描述： | Suppressor of cytokine signaling 1 (SOCS-1) is a member of the SOCS family of proteins, which form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS-1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. SOCS-1 binds to JAKs, inhibiting their kinase activity. |
| 克隆类型： | Rabbit Polyclonal Antibody |
| 亚型： | Rabbit Ig |
| 免疫原： | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human SOCS-1. |
| 适用物种： | H, M, R |
| 应用范围： | E, WB, IHC |
| 应用说明： | E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
| 别名： | Socs 1; SOCS-1; Suppressor of cytokine signaling 1; JAK-binding protein; JAB; STAT-induced STAT inhibitor 1; SSI-1; Tec-interacting protein 3; SOCS1 |
| 形态： | Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 5% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography. |
| 保存条件： | Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 参考文献： |
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文献和实验Detection of Endogenous SOCS1 and SOCS3 Proteins by Immunoprecipitation and Western Blot Analysis
The suppressors of cytokine signalling (SOCS) protein family consist of eight members (SOCS 1–7, and CIS). SOCS1 and SOCS3 are the best-studied family members and have been shown to act as negative feedback inhibitors of the JAK/STAT
Analysis of Suppressor of Cytokine Signalling (SOCS) Gene Expression by Real-Time Quantitative PCR
The Suppressor of Cytokine Signalling (SOCS) proteins are a family of negative regulators characterized by a central SH2 domain and C-terminal SOCS box motif. Cytokine Inducible SH2-containing protein (CIS), SOCS1, 2 and 3 are rapidly
SOCS 蛋白以负反馈环路调控细胞因子的信号转导 当细胞因子末与受体结合时，受体分子相连的Jak和转录因子STAT皆处于未激活状态。受体一旦与配体结合(图12-4B)，跨膜分子间的成簇作用使与之相连的JakPTK彼此靠近，因相互磷酸化而激活。激活的Jak，一方面使受体分子胞内段上的酪氨酸发生磷酸化，招募带有SH2结构域的STAT转录因子，并使得STAT活化而形成同源二聚体，转位后启动多种基因发生转录，行使其生物学功能。 重要的是，STAT同源
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