Serine/threonine-protein kinase PAK 4 (PAK4) activates the JNK pathway. PAK4 plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. PAK4 phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin.
克隆类型:
Rabbit Polyclonal Antibody
亚型:
Rabbit Ig
免疫原:
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PAK4.