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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Notch 1.
- 亚型:
Rabbit Ig
- 形态:
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.
- 保存条件:
Store at -20°C.
- 克隆性:
多克隆
- 标记物:
见下方详细说明
- 适应物种:
H, M, R
- 保质期:
1-2年
- 抗原来源:
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Notch 1.
- 目录编号:
251991
- 级别:
超纯
- 库存:
大量
- 供应商:
Abbiotec
- 宿主:
Rabbit
- 应用范围:
E, IHC
- 浓度:
见详细说明信息
- 靶点:
Notch 1
- 抗体英文名:
Notch 1 Antibody
- 抗体名:
Notch 1 Antibody
- 规格:
0.1 mg
Notch 1 Antibody产品详细介绍:
| 产品名称: | Notch 1 Antibody |
| 说明书: | 【点击查看详细说明及参考图片】 |
| 货号: | 251991 |
| 规格: | 0.1 mg |
| 产品描述: | Neurogenic locus notch homolog protein 1 (Notch 1) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD), Notch 1 forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Notch 1 affects the implementation of differentiation, proliferation and apoptotic programs. Defects in Notch 1 are a cause of bicuspid aortic valve (BAV), a common defect in the aortic valve in which two rather than three leaflets are present. It is often associated with aortic valve calcification and insufficiency. In extreme cases, the blood flow may be so restricted that the left ventricle fails to grow, resulting in hypoplastic left heart syndrome. |
| 克隆类型: | Rabbit Polyclonal Antibody |
| 亚型: | Rabbit Ig |
| 免疫原: | KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Notch 1. |
| 适用物种: | H, M, R |
| 应用范围: | E, IHC |
| 应用说明: | E: 1:1,000-1:10,000; IHC: 1:100-1:500 |
| 别名: | Neurogenic locus notch homolog protein 1; Notch 1; hN1; Translocation-associated notch protein TAN-1; NOTCH1; TAN1 |
| 形态: | Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography. |
| 保存条件: | Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 参考文献: |
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文献和实验polo6892 请问哪个实验室的同学或是老师有Notch1质粒,有点朋友请和我联系下好吗?有事情咨询! 多谢!我的EMAIL :zhouwei5352877@163.com,QQ 286358161,我是武汉大学人民医院实验室的研究生! 谢谢! liudaifu1997 我也感兴趣,等 qinvicky 我们实验室做基因转染的,一直用N2质粒,不过我懂得不是很多~不知能否帮
nafgnaw 想做Notch信号通道,RNA干扰较麻烦,想用通道阻滞剂来代替。 如γ-分泌酶,NICD拮抗剂等。 最好是特异性较好的,能直接阻断或降解NICD. 有人做过这方面的没,望希望指点一下啊。谢~~ nafgnaw 算了,还得靠自己。 chuckdouble gamma-secretase inhibitor, DAPT
nihaifeng 有做寻做notch信号通路的同道吗? 我计划在肾脏方面,做notch信号通路。 和大家一起讨论,可行性。 wanahn8368 我是做肝癌的,也在关注Notch laochu2000 我也准备做。交流交流. ss1002 我也准备做,多交流。QQ:583316182
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