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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
77-67-8
- 规格：
10 mM * 1 mL/500 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 500 mg | 产品价格： | ￥500.0 |
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Ethosuximide
CAS No. : 77-67-8
MCE 国际站：Ethosuximide
产品活性：Ethosuximide 是一种广泛使用的抗癫痫活性分子，可改善多种神经退行性疾病模型的表型，且可阻断低电压激活的 T 型钙通道。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点：Calcium Channel
In Vitro: The efficacy of Ethosuximide in generalized absence epilepsy is thought to be due to blockade of the low voltage activated T-type calcium channel. There is no reduction in total Tau levels in Ethosuximide treated Tau transgenic worms as compare to vehicle controls. The rescuing effect of Ethosuximide is therefore not due to transgene suppression or reduced expression of toxic mutant Tau protein. Quantification of the amount of soluble and insoluble (RIPA-extractable) Tau relative to total Tau levels reveals a significant reduction in aberrantly-folded, insoluble Tau and a corresponding increase in soluble Tau in Ethosuximide-treated compare with untreated worms. Concentrations of 2 μM or more of Ethosuximide not only are found to be less effective than 1 μM concentration of Ethosuximide, but also induce cell toxicity. GABA staining immuno uorescence images show that after treatment with Ethosuximide, GABA positive neuron increases by 3 and 6.5 fold for concentrations of 0.1 and 1 μM, respectively. BrdU staining shows nuclei proliferation after 2 to 3 days of Ethosuximide exposure. The mean of nuclei is 15.98±0.41 for the low concentration of Ethosuximide while it is 25.27±0.48 for the high concentration after Brdu staining. This number is 11.05±0.2 for lithium chloride.
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文献和实验4.32 4.20 4.10 4.03 3.96 3.87 3.77 3.67 3.56 3.45 3.33 9 10 5.46 4.83 4.47 4.24 4.07 3.95 3.85 3.78 3.72 3.62 3.52 3.42 3.31 3.20 3.08 10 11 5.26 4.63 4.27 4.04 3.88 3.76 3.66 3.59 3.53 3.43 3.33 3.23 3.12 3.00 2.88 11 12 5.10 4.47 4.12 3.89
佚名 乙琥胺（ethosuximide）只对失神小发作有效。其疗效不及氯硝西泮，但副作用较少。至今仍是治疗小发作的常用药。对其他型癫痫无效。 常见副作用有嗜睡、眩晕、呃逆、食欲不振和恶心、呕吐等。偶见嗜酸性白细胞增多症和粒细胞缺乏症。严重者可发生再生障碍性 贫血
，以后逐渐增至600～900mg/日或8～10mg/kg/日，分次服用。用于抗癫痫时，剂量可偏大。用于三叉神经痛等症时，剂量一般宜小，每日1.2g，常不能耐受。 扑米酮（primidone,扑痫酮）开始0.06g,3次/日；渐增至0.25g,3次/日。每日总量不超过1.5g。 乙琥胺（ethosuximide）儿童15～35mg/kg/日；成人0.5g，2～3次/日。 丙戊酸钠（sodium valproate）儿童15～60mg/kg/日；成人
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