(±)-Blebbistatin

概述

• 产品名称
  (±)-Blebbistatin
• 描述
  Potent， selective， inhibitor of myosin II
• 生物学描述
  Cell-permeable, reversible inhibitor of non-muscle myosin II. Shows high affinity and selectivity for vertebrate and invertebrate Myosin II (IC₅₀ values 0.5-5 μM). Inhibits actin-activated MgATPase activity and in vitro motility of class II myosins. Also inhibits contraction of the cytokinetic ring. Blocks cell blebbing and disrupts directed cell migration and cytokinesis.
• 纯度
  > 99%

性能

• 化学名称
  (±)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one
• 分子量
  292.34
• 化学结构
  
• 分子式
  C₁₈H₁₆N₂O₂
• CAS编号
  674289-55-5
• PubChem识别号
  3476986
• 存放说明
  Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
• 溶解度概述
  Soluble in DMSO to 100 mM
• 处理

  Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

• SMILES
  Cc2ccc3N=C1N(CCC1(O)C(=O)c3c2)c4ccccc4
• 来源

  Synthetic