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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
+4°C 干燥
- 保质期：
12个月
- 英文名：
Flumazenil
- 供应商：
上海汇谱仪器有限公司
- CAS号：
78755-81-4
- 规格：
10 mg
概述
- 产品名称
Flumazenil - 描述
Benzodiazepine antagonist - 别名
- Ro 15-1788
- 生物学描述
Selective non-competitive benzodiazepine antagonist with low affinity for α4- and α6-subunits - 纯度
> 99%
性能
- 化学名称
8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1 ,4]benzodiazepine-3-carboxylic acid ethyl ester - 分子量
303.29 - 化学结构
- 分子式
C15H14FN3O3 - CAS编号
78755-81-4 - PubChem识别号
3373 - 存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. - 溶解度概述
Soluble in DMSO to 25 mM (with warming) and in ethanol to 5 mM (with heating) - 处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- SMILES
O=C(OCC)c3ncn2c3CN(C)C(=O)c1cc(F)ccc12 - 来源
Synthetic
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文献和实验有2例与苯二氮类中毒有关。全部病例均无明显药物不良反应。提示氟马西林可安全有效地用于诊断及治疗药物中毒所致昏迷。 Use of Flumazenil in the Diagnosis and Treatment of Coma Patients with Suspected Drug Intoxication LI Xiu-Qing XIONG Hui CHEN Xu-Yan WANG Bo LI Gui-Lian DING Wen-Hui
Saturation Assays of Radioligand Binding to Receptors and Their Allosteric Modulatory Sites
10 mM flunitrazepam (see recipe ) 100 nM [3 H]flumazenil (i.e., [3 H]Ro15‐1788; see recipe )
Benzodiazepine Binding to GABAA Receptors
[3 H]flumazenil binding to mouse brain membranes. (A ) Analysis of [3 H]flumazenil saturation binding. Membranes prepared from whole mouse brains (∼0.1 mg protein/tube) were incubated in 50 mM Tris‐citrate, pH 7.4, containing various concentrations
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