SNX 482

概述

• 产品名称
  SNX 482
• 描述
  R-Type Ca²⁺ (Ca_v2.3) channel blocker
• 生物学描述
  Peptide toxin that naturally occurs in the venom of the spider Hysterocrates gigas. Selectively blocks Ca_v2.3 (α1E, R-type) channels in a voltage dependent manner (IC₅₀ = 15-30 nM). At higher concentrations, also blocks Ca_v2.1 channels in chromaffin cells.
• 纯度
  > 98%

性能

• 分子量
  4495.01
• 化学结构
  
• 分子式
  C₁₉₂H₂₇₄N₅₂O₆₀S₇
• CAS编号
  203460-30-4
• 序列
  GVDKAGCRYMFGGCSVNDDCCPRLGCHSLFSYCAWDLTFSD (Modifications: Disulfide bonds: 7-21, 14-26, 20-33)
• 存放说明
  Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
• 溶解度概述
  Soluble in water
• 处理

  Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

• 来源

  Synthetic