AICAR (Acadesine/AICA riboside

概述

• 产品名称
  AICAR (Acadesine/AICA riboside)
• 描述
  Cell-permeable activator of AMP-activated protein kinase
• 别名
  • Acadesine
  • AICA riboside
• 生物学描述
  Cell-permeable activator of AMP-activated protein kinase. Is taken up into cells by adenosine transporters and phosphorylated by adenosine kinase to the active nucleotide ZMP (5-aminoimidazole-4-carboxamide ribonucleoside), which mimics effects of AMP on the AMPK system. Activein vivo and in vitro.
  
  Also available in simple stock solutions (ab146713) - add 1 ml of water to get an exact, ready-to-use concentration.
• 纯度
  > 98%

性能

• 化学名称
  5-Amino-1-[(2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl]-1H-imidazole-4-carboxamide
• 分子量
  258.23
• 化学结构
  
• 分子式
  C₉H₁₄N₄O₅
• CAS编号
  2627-69-2
• PubChem识别号
  17513
• 存放说明
  Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
• 溶解度概述
  Soluble in water to 50 mM and in DMSO to 100 mM (with heating)
• 处理

  Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

• SMILES
  NC(=O)c2ncn([C@@H]1O[C@H](CO)[C@H](O)[C@@H]1O)c2N
• 来源

  Synthetic