Iminodyn™ 22

概述

• 产品名称
  Iminodyn™ 22
• 描述
  Potent， broad spectrum dynamin inhibitor
• 生物学描述
  Potent, broad spectrum dynamin inhibitor. (IC₅₀ values are 450 and 390 nM for inhibition of dynamin I and II GTPase, respectively). Binds to the GTPase domain at an allosteric site and displays uncompetitive antagonism with respect to GTP. Inhibits receptor mediated endocytosis (RME) and synaptic vesicle endocytosis (SVE) (IC₅₀ values are 10.7 and 108 μM, respectively).
• 纯度
  > 98%
• 常规说明
  Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Iminodyn™ is a trademark of Children's Medical Research Institute and Newcastle Innovation Ltd.

性能

• 化学名称
  N,N'-(Propane-1,3-diyl)bis(7,8-dihydroxy-2-imino-2H-chromene-3-carboxamide)
• 分子量
  480.43
• 化学结构
  
• 分子式
  C₂₃H₂₀N₄O₈
• 存放说明
  Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
• 溶解度概述
  Soluble in DMSO to 25 mM
• 处理

  Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

• SMILES
  Oc2ccc1C=C(C(=N)Oc1c2O)C(=O)NCCCNC(=O)C3=Cc4ccc(O)c(O)c4OC3=N
• 来源

  Synthetic