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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Glycyrrhizin
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1405-86-3
- 规格：
10 mM * 1 mL/50 mg/100 mg/500 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 50 mg | 产品价格： | ￥500.0 |
| 规格： | 100 mg | 产品价格： | ￥700.0 |
| 规格： | 500 mg | 产品价格： | ￥2100.0 |
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Glycyrrhizic acid
CAS No. : 1405-86-3
MCE 国际站：Glycyrrhizic acid
产品活性：Glycyrrhizic acid 是甘草里面的活性成分三萜皂苷，为 HMGB1 的拮抗剂，有用于肿瘤、糖尿病等研究的潜力。
研究领域：Anti-infection
作用靶点：Virus Protease
In Vitro: Glycyrrhizic acid shows a series of anti-cancer-related pharmacological activities, such as broad-spectrum anti-cancer ability, resistance to the tissue toxicity caused by chemotherapy and radiation, drug absorption enhancing effects and anti-multidrug resistance (MDR) mechanisms, as a carrier material in drug delivery systems.
In intestinal NCI-H716 cells that secretes GLP-1, Glycyrrhizic acid promotes GLP-1 secretion with a marked elevation of calcium levels. Glycyrrhizic acid can enhance GLP-1 secretion through TGR5 activation.
Glycyrrhizic acid can form a stable transparent low-molecular-weight hydrogels (LMWHs) at 37°C in physiological phosphate buffered saline (PBS) with nanoclusters as the microstructures.
In Vivo: In type 1-like diabetic rats induced by streptozotocin (STZ-treated rats), Glycyrrhizic acid increases the level of plasma GLP-1, which is blocked by triamterene at a dose sufficient to inhibit Takeda G-protein-coupled receptor 5 (TGR5).
Glycyrrhizic acid (Glycyrrhizic acid; 50 mg/kg, i.p.) significantly decreases the levels of TgAb, HMGB1, TNF-α, IL-6, IL-1β in mice.
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Assessment of Insulin Secretion in the Mouse
sequence ( 1 ). The resulting 86-amino acid product folds through the formation of three disulfide bridges between Cys 7 -Cys 72 , Cys 19 -Cys 85 , and Cys 71 -Cys 76 to produce the prohormone
Secondary structure of prion mRNA
is located at nt 140 to 165 (nt 149 to 174 for the ruminants) relative to the start of the ORF. On the amino acid level the triplet 5'-CCH-3' of the HP C loop represents the first amino acid of the octarepeat region, which consists of five nearly perfect
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