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- 2026年05月21日
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- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1338934-20-5
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1286.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥546.0 |
| 规格： | 5 mg | 产品价格： | ￥1738.0 |
| 规格： | 10 mg | 产品价格： | ￥2663.0 |
| 规格： | 25 mg | 产品价格： | ￥4263.0 |
| 规格： | 50 mg | 产品价格： | ￥5763.0 |
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MKC9989
CAS No. : 1338934-20-5
MCE 国际站：MKC9989
产品活性：MKC9989 是一种 HAA 抑制剂，且能抑制 IRE1α 其 IC50 值在 0.23 μM 至 44 μM 的范围之间。
研究领域：Cell Cycle/DNA Damage
作用靶点：IRE1
In Vitro: At 10 μM concentration, MKC9989 completely inhibits both basal and thapsigargin induced splicing of XBP1 mRNA. These effects are observed even in cells pre-treated with thapsigargin, indicating that MKC9989 can fully reverse the onset of XPB1 splicing after the UPR is initiated. In parallel analysis, MKC9989, significantly stabilizes the RIDD target CD59 mRNA when co-administered with thapsigargin relative to thapsigargin treatment alone and modestly increases levels of CD59 mRNA in non-stressed cells, the latter likely reflects the inhibition of baseline RIDD activity. In contrast to effects on XBP1 splicing, MKC9989 moderately stabilizes CD59 levels when administered 2 hour post treatment with thapsigargin. Finally, the potency of MKC9989 against the splicing of XBP1 mRNA (EC50=0.33 μM) is comparable to its potency against RNA cleavage in vitro.
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