- ￥1950 - 3100
- MedChemExpress(MCE)
- 美国
- HY-101534
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1191044-58-2
- 规格：
10 mM * 1 mL/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2150.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1950.0 |
| 规格： | 10 mg | 产品价格： | ￥3100.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
GSK1059865
CAS No. : 1191044-58-2
MCE 国际站：GSK1059865
产品活性：GSK1059865是有效地食欲素1受体 (orexin 1 receptor) 拮抗剂。
研究领域：GPCR/G Protein | Neuronal Signaling
作用靶点：Orexin Receptor (OX Receptor)
In Vivo: Treatment with GSK1059865 significantly decreases ethanol drinking in a dose-dependent manner in CIE-exposed mice. In contrast GSK1059865 decreases drinking in air-exposed mice only at the highest dose used. There is no effect of GSK1059865 on sucrose intake. GSK1059865 (0.3 nM-10 nM) produces non-surmountable antagonism with a dose-dependent rightward shift of the OXA EC50 and a concomitant decrease of the agonist maximal response. The calculated pKB value is 8.77±0.12 for GSK1059865. GSK1059865 (0.1-3.3 μM) produces a classical surmountable profile with parallel rightward shift of the OXA EC50 without depression of the agonist maximal response. Intraperitoneal administration of GSK1059865 produces a region-dependent inhibition of yohimbine-induced relative cerebral blood volume response. The administration of GSK1059865 per se produces a weak relative cerebral blood volume increase in several brain regions. GSK1059865-pretreated animals exhibit slightly higher baseline mean arterial blood pressure values than controls.
相关产品：Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Neuronal Signaling Compound Library | Endocrinology Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Orexin A (human, rat, mouse) (TFA) | Almorexant | SB-334867 free base | JNJ-10397049 | Danavorexton | Seltorexant | Orexin 2 Receptor Agonist | YNT-185 dihydrochloride | EMPA | Filorexant | SB-674042 | TCS-OX2-29 | MK-1064 | TCS 1102 | Orexin B, human TFA | SB-649868 | Cudarolimab | OXA(17-33) | SB-408124 | MK-3697 | Revdofilimab | Vornorexant | ACT-335827 | ACT-462206 | Firazorexton hydrate
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验以下是美国冷泉港(CSHL)Hannon领导的研究小组报道的29bp shRNA可以在哺乳动物中起RNAi效应： Paddison PJ, et al. Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev. 2002 Apr 15;16(8):948-58. 免费全文网址：http://www.genesdev.org/cgi/content/full/16
DNA extraction from Mutation Detection Enhancement (MDE) Gel Stained with Silver Nitrate
'); these amplified a 146-bp fragment of exon 3 of the CTNNB1 gene, encompassing the sequence for GSK-3¦Â phosphorylation. The PCR conditions consisted of 1 cycle at 95˚C for 5 min; 40 cycles at 95˚C for30 sec, 55˚C for 45 sec, and 72˚C for 75 sec; at a final
Wnt/β-catenin信号通路在实验性大鼠肝癌形成过程中的作用
Wnt /β-catenin信号转导通路是一条在生物进化中极为保守的通路。在正常的体细胞中，β-catenin只是作为一种细胞骨架蛋白在胞膜处与E-cadherin形成复合体对维持同型细胞的黏附、防止细胞的移动发挥作用。只有当细胞外Wnt信号分子与细胞膜上特异性受体Frizzled蛋白结合激活胞内的d ishevelled(散乱的)蛋白导致GSK3B失活，使α-catenin避免被磷酸化而遭降解的命运 , β-catenin才能在胞质中积累起来。当胞质中B-catenin的浓度达到一定水平
技术资料暂无技术资料 索取技术资料
