Astrocytes make up the majority of the cells in the mammalian brain. They are the most variable in type, most intimately associated with all parts of neurons, and thus most functionally interesting in their relationships with neurons. They provide structural, trophic, and metabolic support to neurons and modulate synaptic activity. Impairment of these astrocyte functions during stroke and other insults can critically influence neuron survival. Furthermore, astrocytes have been implicated in the pathological processes of many neurological diseases. Long-term recovery after brain injury, through neurite outgrowth, synaptic plasticity, or neuron regeneration, is influenced by astrocyte surface molecule expression and trophic factor release. In addition, the death or survival of astrocytes themselves may affect the ultimate clinical outcome. Recognition of the importance of astrocytes in nervous system functioning is increasing, specifically regarding the modulation of neural activity. Much of what we have learned about astrocytes is from the in vitro studies and astrocyte cultures are continuing to provide a useful tool in exploring the diverse property of these cells.HA-bs from AcceGen Research Laboratories are isolated from human brain stem. 在哺乳动物的大脑中,星形胶质细胞占大多数。它们的类型最多变,与神经元的所有部分联系最密切,因此在功能上最有趣的是它们与神经元的关系。它们为神经元提供结构、营养和代谢支持,并调节突触活动。这些星形胶质细胞在中风和其他损伤过程中的功能受损会严重影响神经元的存活。此外,星形胶质细胞在许多神经系统疾病的病理过程中都有牵连。脑损伤后神经突生长、突触可塑性或神经元再生的长期恢复受星形细胞表面分子表达和营养因子释放的影响。此外,星形胶质细胞本身的死亡或生存可能影响最终的临床结果。人们越来越认识到星形胶质细胞在神经系统功能中的重要性,特别是在调节神经活动方面。我们对星形胶质细胞的了解大多来自体外研究,星形胶质细胞培养继续为探索这些细胞的多样性提供了有用的工具。AcceGen研究实验室的HA-bs是从人类脑干中分离出来的。
Quality Control
All cells test negative for mycoplasma, bacteria, yeast, and fungi.