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- 2026年02月06日
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| Source | Human Cells |
| Description | Recombinant Human Vascular Endothelial Growth Factor A is produced by our Mammalian expression system and the target gene encoding Ala27-Arg191 is expressed. |
| Names | Vascular Endothelial Growth Factor Isoform 165, VEGF165 |
| Accession # | P15692-4 |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. |
| Shipping | The product is shipped at ambient temperature. |
| Reconstitution | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. |
| Endotoxin | Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test. |
| Amino Acid Sequence |
APMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEG LECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQENPCGPCSERRKHLFVQ DPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
|
| Background | Human Vascular endothelial growth factor (VEGF), also known as VEGF-A and vascular permeability factor (VPF), belongs to the platelet-derived growth factor family of cysteine-knot growth factors. It is a potent activator in vasculogenesis and angiogenesis both physiologically and pathologically. VEGF-A has 8 differently spliced isoforms, of which VEGF165 is the most abundant one. VEGF165 is a disulfide-linked homodimer consisting of two glycosylated 165 amino acid polypeptide chains. VEGF stimulates the cellular response through binding to tyrosine kinase receptors VEGFR1 and VEGFR2 on the cell surface. It is widely accepted that VEGFR2 mediate almost all of the known cellular responses to VEGF while the function of VEGFR1 is less defined and is thought to modulate the VEGFR2 signaling. |
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文献和实验9.12 Cell Res：VEGFA 信号通路在血管稳态调控过程中的两面性
① Cell Res：VEGFA 信号通路在血管稳态调控过程中的两面性内皮细胞响应信号刺激对血管形态、稳态和功能的调控至关重要。血管内皮生长因子 A (VEGFA) 自 20 世纪 80 年代被鉴定以来，其主要功能之一便是促进血管生长。中国科学院上海营养与健康研究所潘巍峻研究组在斑马鱼中发现，在 VEGFA 刺激条件下，cds2 基因突变胚胎的血管能够发生血管退化。斑马鱼活体成像技术表明，cds2 突变体的内皮细胞受 VEGFA 刺激能够通过逆向迁移和细胞凋亡来诱导血管退化。小鼠
坏死因子（Tumornecrosisfactor,TNF)根据其产生来源和结构不同，可分为TNF-α和TNF-β两类，前者由单核-巨噬细胞产生，后者由活化T细胞产生，又名淋巴毒素。TNF除具有杀伤肿瘤细胞外，还有免疫调节、参与发热和炎症的发生。 5，转化生长因子-β家族（Transforminggrowthfactor-βfamily,TGF-βfamily)主要包括TGF-β1、TGF-β2、TGF-β3、TGFβ1β2以及骨形成蛋白（BMP）等。 6.趋化因子家族（Chemokinefamily)包括两个亚族：（1）C-X-C
Chick Chorioallantoic Membrane (CAM) Assay
Dickinson, Bedford, MA) was diluted to a final concentration of 10 mg/ml with DMEM and directly pipetted onto meshes. Nylon mesh with 250 μm2 openings were cut into 4 mm x 4 mm squares and autoclaved. In preparation for polymerization, meshes were placed
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