- 询价
- 江蓝纯
- P106869
- 2025年07月05日
9 年钻石会员
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保质期：
两年
- 英文名：
Paclitaxel
- 库存：
99
- 供应商：
江蓝纯
- CAS号：
33069-62-4
属性
| 旋光率 | -49 ° (C=1, MeOH) |
| 密度 | 1.3900 |
| 熔点 | 213-216°C |
| 溶解性 | Soluble in ethanol (~1.5 mg/ml), DMSO (5 mg/ml), acetonitrile, methanol (50 mg/ml), chloroform, 1:10 DMSO:PBS(pH 7.2) (~0.1 mg/ml), and DMF (~5 mg/ml). Insoluble in water. |
| 存贮条件 | 储存温度2-8°C |
描述
| 产品介绍 | Paclitaxel是一种微管聚合物稳定剂，作用于人内皮细胞，IC50为0.1 pM |
| 别名 | Taxol;Taxol |
| 生化机理 | Taxol, an antineoplastic and antimicrotubule agent, posses mechanisms of cytotoxic action and has a broad antineoplastic spectrum compared to the vinca alkaloids. Studies have shown that Taxol is an inhibitor of neurite outgrowth and initiation by destroying normal control of microtuble assemly in growing neurites and removing tubulin from the cytoplasm. At lower concentrations Taxol displays the capacity to slightly enhance the mechanisms of microtubule assembly in neurons, and in turn changes the morphogenetic properties of growing neurites. The mechanism for microtuble formation occurs by binding of Taxol to the N-terminal region of β-tubulin. These new microtubules are highly stable and resist depolymerization therefore preventing normal cell division and arresting cell cycle at the G2/M phase. It has been reported that Taxol also causes apoptotic cell death, internucleosomal DNA fragmentation, and inhibition of protein isoprenylation. Taxol is a potential activator of PKA and Raf |
| 应用 | 有效的抗肿瘤的药物;结合β-微管蛋白的N -端区域，促进了高度稳定的微管形成体，抵制解聚，防止正常细胞分裂和捕获在细胞周期的G2 / M期。 |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
紫杉醇 ,99%
询价
