Cleaved-PARP1 (D214) 多克隆抗体

Western Blot（WB）已验证样本:A549
免疫组织化学（IHC）已验证样本:Human lung cancer
免疫荧光（IF）已验证样本:Rat spleen

WB 1:500-2000, IHC 1:50-300, IF 1:50-300

Polyclonal

IgG

Synthesized peptide derived from the Internal region of human PARP-1

Cleaved-PARP1 (D214)

ADP-ribosyltransferase diphtheria toxin-like 1;ADPRT 1;ADPRT;ADPRT1;APOPAIN;ARTD1;NAD(+) ADP-ribosyltransferase 1;PARP;PARP-1;PARP1;PARP1;Poly [ADP-ribose] polymerase 1;Poly ADP ribose polymerase 1;Poly[ADP-ribose] synthase 1;PPOL;SCA1抗体

P09874

113kDa

24kDa

Nucleus. Nucleus, nucleolus. Localizes at sites of DNA damage.

1 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Affinity purification

Cancer; Cell Biology; Epigenetics and Nuclear Signaling; Metabolism

Unconjugated

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.