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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
2-8℃
- 保质期:
见包装
- 英文名:
Diosgenin
- 库存:
大量现货
- 供应商:
上海研谨生物
- CAS号:
512-04-9
- 规格:
20mg
薯蓣皂苷元
分析标准品,HPLC≥98%
Diosgenin
CAS号:512-04-9
分子式:C27H42O3
分子量:414.61
MDL:MFCD00016887
别名:薯蓣皂素;地奥配质
|
货号 |
规格/参数/品牌 |
价格 |
货期 |
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YJ-B21177-20mg |
分析标准品,HPLC≥98% |
¥150.00 |
现货 |
|
YJ-B21177-50mg |
分析标准品,HPLC≥98% |
¥260.00 |
现货 |
|
YJ-B21177-100mg |
分析标准品,HPLC≥98% |
¥330.00 |
现货 |
|
YJ-B21177-200mg |
分析标准品,HPLC≥98% |
¥500.00 |
现货 |
|
JS31698-5g |
≥98% |
¥165.00 |
现货 |
|
JS31698-25g |
≥98% |
¥315.00 |
现货 |
|
JS31698-100g |
≥98% |
¥690.00 |
现货 |
|
JS31698-500g |
≥98% |
¥2400.00 |
2-3天 |
产品介绍
药理药效:薯蓣皂素是一种植物类固醇,诱导结肠癌细胞凋亡和诱导骨肉瘤细胞凋亡,细胞周期阻滞和COX活性。
熔点:205-208℃
沸点:527.1 ℃ at 760 mmHg
比旋光度:D25 -129° (c = 1.4 in CHCl3)
外观:白色至淡黄色片状或针状结晶
溶解性:二氯*甲烷:5mg/ml(需超声)
乙醇:1mg/ml(需超声)
DMSO:基本不溶
HPLC检测建议用二氯*甲烷溶解后再用甲醇稀释,纯甲醇溶解性不好。
储存条件:2-8℃
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文献和实验参考文献(38篇)
38. [IF=4.7] Guoliang Yin et al."Diosgenin attenuates nonalcoholic fatty liver disease through mTOR-mediated inhibition of lipid accumulation and inflammation."CHEMICO-BIOLOGICAL INTERACTIONS.2025 Jan;405:111306
37. [IF=3.9] Qile Xia et al."Inhibitory effect and mechanism of purified saponin from Polygonatum cyrtonema Hua on human ovarian cancer cell A2780."FOOD AND CHEMICAL TOXICOLOGY.2025 Mar;:115368
36. [IF=8.5] Jing Pan et al."Bioactivity and application potential of O/W emulsions derived from carboxylic acid-based NADES-extracted total saponins from Polygonatum cyrtonema Hua."FOOD CHEMISTRY.2025 Jan;463:141363
35. [IF=4.2] Decheng Meng et al."Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic SIRT1/PGC-1α pathway."EUROPEAN JOURNAL OF PHARMACOLOGY.2024 Aug;977:176737
34. [IF=4.8] Wenfei Yu et al."Diosgenin attenuates metabolic-associated fatty liver disease through the hepatic NLRP3 inflammasome-dependent signaling pathway."INTERNATIONAL IMMUNOPHARMACOLOGY.2024 Sep;138:112581
33. [IF=4.7] Xinyu Li et al."Gut microbiota modification by diosgenin mediates antiepileptic effects in a mouse model of epilepsy."JOURNAL OF NEUROCHEMISTRY.2023 Dec;:
32. [IF=7.3] Rui-Fang Dong et al."Discovery of a potent inhibitor of chaperone-mediated autophagy that targets the HSC70-LAMP2A interaction in non-small cell lung cancer therapy."BRITISH JOURNAL OF PHARMACOLOGY.2023 Jun;:
31. [IF=5.195] Suwen Chen et al."Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic FXR-SHP-SREBP1C/PPARα/CD36 pathway."EUROPEAN JOURNAL OF PHARMACOLOGY.2023 Aug;952:175808
30. [IF=5.168] Pan Wang et al."Discovery and characterization of novel ATP citrate lyase inhibitors from natural products by a luminescence-based assay."CHEMICO-BIOLOGICAL INTERACTIONS.2022 Nov;367:110199
29. [IF=6.525] Lixia Chen et al."A Novel Diosgenin-Based Liposome Delivery System Combined with Doxorubicin for Liver Cancer Therapy."Pharmaceutics.2022 Aug;14(8):1685
28. [IF=6.417] Chen Zhou et al."22R- but not 22S-hydroxycholesterol is recruited for diosgenin biosynthesis."Plant Journal. 2021 Dec 07
27. [IF=5.753] Jianghong Gao et al."Molecular Cloning and Functional Characterization of a Sterol 3-O-Glucosyltransferase Involved in Biosynthesis of Steroidal Saponins in Trigonella foenum-graecum.."Front Plant Sci. 2021 Dec;12:809579-809579
26. [IF=3.645] Shuo Gu et al."Develop a stepwise integrated method to screen biomarkers of Baihe-Dihuang Tang on the treatment of depression in rats applying with composition screened, untargeted, and targeted metabolomics analysis."Journal Of Separation Science. 2022 M
25. [IF=2.289] Zhou Shun et al."Anthelmintic efficacy of natural saponins against Gyrodactylus kobayashii in goldfish (Carassius auratus) and their 3D-QSAR analysis."Parasitol Res. 2021 Mar;120(3):1143-1150
24. [IF=3.998] Chengfei Zhang et al."Transcriptome analysis of the effect of diosgenin on autoimmune thyroiditis in a rat model."Sci Rep-Uk. 2021 Mar;11(1):1-12
23. [IF=4.242] Shun Zhou et al."Anthelmintic efficacy of 35 herbal medicines against a monogenean parasite, Gyrodactylus kobayashii, infecting goldfish (Carassius auratus)."Aquaculture. 2020 May;521:734992
22. [IF=5.275] Liangqun Li et al."Microbial transformation of diosgenin to diosgenone by Wickerhamomyces anomalus JQ-1 obtained from Naxi traditional Jiu Qu."Bioorg Chem. 2020 Jan;95:103508
21. [IF=5.923] Lixiu Hou et al."Genome-Wide Identification of CYP72A Gene Family and Expression Patterns Related to Jasmonic Acid Treatment and Steroidal Saponin Accumulation in Dioscorea zingiberensis."Int J Mol Sci. 2021 Jan;22(20):10953
20. [IF=0.533] P Wang et al."Ionic Liquid-Based Ultrasonic/Microwave-Assisted Extraction of Steroidal Saponins from Dioscorea zingiberensis C. H. Wright."Trop J Pharm Res. 2014 Sep;13(8):1339-1345
19. [IF=2.998] Lei Lei et al."Preparation of diosgenin from Dioscorea zingiberensis C. H. Wright by stepwise biocatalysis-foam separation-preparative high-performance liquid chromatography (P-HPLC)."Eur Food Res Technol. 2018 Aug;244(8):1447-1452
18. [IF=4.759] Mengshun Liu et al."Folding fan mode counter-current chromatography offers fast blind screening for drug discovery. Case study: Finding anti-enterovirus 71 agents from Anemarrhena asphodeloides."J Chromatogr A. 2014 Nov;1368:116
17. [IF=5.64] Wu Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum."Front Microbiol. 2015 Dec;0:1466
16. [IF=9.297] Peng Wang et al."Conversion of steroid saponins into diosgenin by catalytic hydrolysis using acid-functionalized ionic liquid under microwave irradiation."J Clean Prod. 2014 Sep;79:265
15. Wang, Peng, et al. "Conversion of steroid saponins into diosgenin by catalytic hydrolysis using acid-functionalized ionic liquid under microwave irradiation." Journal of cleaner production 79 (2014): 265-270.https:##doi.org/10.1016/j.jclepro.2014.05.041
14. 李慧敏,郑淘,曾艺琼,范郁冰,李卫真,严建业,赵利平,郑慧,杨勇.AHP-CRITIC权重分析法综合优选玉竹全粉改性工艺[J].食品与发酵工业,2021,47(05):138-146.
13. 胡佳莉. 红曲黄精发酵工艺及免疫调节和降血脂作用研究[D].广东药科大学,2020.
12. 周晓,李婧琳,邹俊波,张小飞,郭东艳,程江雪,史亚军,石心红,贾晓斌.粒子设计对参苓白术散在大鼠体内药动学过程的影响[J].中草药,2020,51(19):4925-4933.
11. 石鸿辉 苑广伟 廖正睿 等. 不同菌种发酵对辣木茎叶粉的营养价值及其抗氧化活性的影响[J]. 食品工业科技 2019 040(009):91-97 104.
10. 张泽锐, 黄申, 刘京晶,等. 多花黄精和长梗黄精花主要营养功效成分[J]. 中国中药杂志, 2020, v.45(06):123-127.
9. 杨亚利 刘佳 张鹏 等. 4种重楼不同部位薯蓣皂苷及皂苷元含量的分析[J]. 时珍国医国药 2016(5):1035-1038.
8. 胡佳莉, 刘林, 李钟,等. 黄精发酵过程中有效成分含量与色泽的相关性[J]. 中国实验方剂学杂志, 2020(15).
7. 陈振兴,赵瑞芝.薯蓣皂苷元对盐酸米托蒽醌诱导耐药子宫肉瘤细胞MES-SA/MX2凋亡的增敏作用[J].中国药学杂志,2017,52(24):2157-2160.
6. 孙蕊, 牛洁, 曹芳,等. 薯蓣皂苷元对LPS诱导的人胚肺成纤维细胞的干预机制研究[J]. 环球中医药, 2019, 012(007):988-993.
5. 赵杨, 曾禾鑫, 成志强,等. 盐蒺藜的制备及质量控制研究[J]. 时珍国医国药, 2019, v.30;No.288(08):98-100.
4. 李会, 张佳佳, 梁静怡,等. 基于酶法辅提和微波酸解的黄姜薯蓣皂苷元清洁生产工艺[J]. 食品科学, 2012, 033(020):94-98.
3. 袁志鹰, 罗林明, 陈乃宏,等. 基于UPLC-Q-TOF-MS法分析百合珠芽化学成分及其薯蓣皂苷元抗肿瘤活性研究[J]. 天然产物研究与开发, 2019, 31(05):808-813.
2. 杨南南 李会 吴燕 张晓梅 许正宏 史劲松.Gibberella intermedia WX12产特异性糖苷酶的发酵工艺优化[J].食品与生物技术学报 2016 35(10):1028-1034.
1. 赵丽蓉 罗汉 相英龙 等. Box-Benhken响应面法优化微波提取黄精总皂苷的条件[J]. 中国现代中药 2018 20(008):1010-1015.
目的要求: 1.掌握甾体皂苷元(亲脂性和中性成分)的提取方法。 2.熟悉薯蓣皂苷元的性质及鉴定法。 简介: 薯蓣皂苷元(Diosgenin)是一种甾体皂苷元,分子式(C27H42O31),分子量414.61,为白色结晶,mp204~207℃,[ ]25D-129.3(CHCl3),溶于一般有机溶剂和醋酸,不溶于水。目前,是制造多种甾体药物如口服避孕药(I号,II号避孕药片)和甾体激素(如可的松)等的重要原料。在植物界主要分布在薯蓣科薯蓣属(Dioscorea)植物中,我国
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