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ACT 178882
CAS No. : 1007392-69-9
MCE 国际站：ACT 178882
产品活性：ACT178882 是一种新的 Renin 抑制剂，其 IC50 值为 1.4 nM。
研究领域：Metabolic Enzyme/Protease
作用靶点：Renin
In Vitro: The median time to Cmax (tmax) for ACT 178882 is prolonged from 3.5 to 5.0 h by diltiazem whereas its apparent terminal half-life (t½) is unaffected by diltiazem, 22.9 and 24.2 h for treatments A and B, respectively. Using treatment A as reference, the geometric mean ratio (90% CI) is 1.62 (1.36 to 1.94) for Cmax and 2.02 (1.75 to 2.34) for AUC∞, indicating a significant interaction between ACT 178882 and diltiazem.
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文献和实验The standard assay for monitoring anticoagulation during extracorporeal life support (ECLS) is the activated clotting time (ACT) test, with celite, kaolin, and glass beads being the most commonly used activators to initiate contact activation
Identification of Substrates for Adenosine Deaminases That Act on RNA
Adenosine deaminases that acts on RNA (ADARs) are RNA-editing enzymes that convert adenosine to inosine in double-stranded RNA. This chapter provides a detailed protocol for identifying inosine-containing RNAs. Candidate ADAR substrates
消化管 alimentary canal， alimentary tr-act，digestive tract
消化管 alimentary canal， alimentary tr-act， digestive tract 亦称肠管。指从口到肛门的食物通道。但是，扁形动物的消化管没有肛门的分化，而终止于盲囊，食物的残渣经口排出体外。鱼类，由于有鳃裂，消化管在咽部与外界相通。两栖类以上的动物，食管在咽部与呼吸器官（鼻腔、气管）相连接。此外，哺乳类以外的动物，它们的肠末端开口于总排泄腔，而哺乳动物由于形成了会阴部，生殖管和输尿管的开口与消化管分开，消化管通过肛门与外界相通。脊椎动物消化管的主要
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