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PeproTech重组人TGF-beta1-Mammalian 2ug

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PeproTech重组人TGF-beta1-Mammalian 2ug

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  • 货号: 100-21-2
    英文名: Recombinant Human TGF-beta1-Mammalian
    CAS号:
    数量: 大量
    保存条件: -20oC
    保质期: 1年以上
    供应商: PeproTech(派普泰克)
     

    Synonyms :

    Transforming Growth Factor-beta1, Differentiation inhibiting factor, Cartilage-inducing factor

    Description :

    The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts and recently it has been implicated in the formation of skin tumors. Human TGF-β1 is a 25.0 kDa protein with each subunit containing 112 amino acid residues, linked by a single disulfide bond.

    Catalog #:

    100-21

    Source :

    A293 cells

    Purity :

    Greater than 98% by SDS-PAGE gel and HPLC analyses.

    Endotoxin Level :

    Endotoxin level is less than 0.1 ng per µg (1EU/µg).

    Biological Activity :

    The ED 50 was determined by TGF-beta1's ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.

    Selected References :

    Selected List of References Citing This Product

    AA Sequence :

    ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS

    PubMed Link :

    TGF+AND+beta+AND+1

    Country of Origin :

    USA

     

     

     

    Size A 2µg $80   
     
    Size B 5µg $195   
     
    Size C 1mg $9800   
     

     


     

    Special Sizes:
    Many products can be ordered in custom sizes. Please click here to contact with your request.

     

    Usage:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

  • PeproTech重组人TGF-beta1-Mammalian 2ug

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