- ¥1280
- BIOSS
- 北京
- YSm-4792M
- 2025年07月15日
- IHC-P=1:50-100 IHC-F=1:50-1267 （石蜡切片需做抗原修复） not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
- rabbit
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
KLH conjugated synthetic peptide derived from human PRODH
- 亚型：
IgG
- 形态：
液态/冻干粉
- 保存条件：
Store at -1362 °C
- 克隆性：
多克隆
- 宿主：
rabbit
- 应用范围：
IHC-P=1:50-100 IHC-F=1:50-1267 （石蜡切片需做抗原修复） not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
- 浓度：
1mg/1ml
- 规格：
0.2ml/0.1ML
英文名称CEA
中文名称癌胚抗原抗体
别 名Carcino Embryonic Antigen CEA; CEACAM 5; CEACAM-5; Carcinoembryonic antigen; Carcinoembryonic antigen related cell adhesion molecule 5; CD66e; CD66e antigen; CEA; CEACAM5; DKFZp781M2392; Meconium antigen 100.
Specific References (1) | bsm-4792M has been referenced in 1 publications.[IF=5.83] Ren, Kewei, et al. "Target-Driven Triple-Binder Assembly of MNAzyme for Amplified Electrochemical Immunosensing of Protein Biomarker." Analytical Chemistry (2015). other ; PubMed:25557949
规格价格50ul 100ul
研究领域肿瘤 免疫学 干细胞 肿瘤细胞生物标志物
抗体来源Mouse
克隆类型Monoclonal
克 隆 号4F3
交叉反应 Human,
产品应用ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量150-200kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CEA/CD66e/CEACAM5:41-140/702
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
癌胚抗原抗体产品介绍background:
CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM 1, CEACAM 3-CEACAM 8) and 11 pregnancy-specific glyco-protein (PSG 1-PSG 11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/ CEACAM 5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.
Function:
Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.
Subunit:
Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.
Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor
Tissue Specificity:
Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
Similarity:
Belongs to the immunoglobulin superfamily. CEA family.
Contains 7 Ig-like (immunoglobulin-like) domains.
SWISS:
P06731
Gene ID:
1048
Database links:
Entrez Gene: 1048 Human
Omim: 114890 Human
SwissProt: P06731 Human
Unigene: 709196 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
癌胚抗原抗体CEA是一种胚胎性抗原，主要存在于胎儿消化道上皮组织，胰腺和肝癌中。CEA广泛存在各种上皮性肿瘤，尤其是胃肠道恶性肿瘤，CEA分布阳性类型与肿瘤的恶性度有关。CEA与EMA一样可作为上皮性恶性肿瘤的重要标记。
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文献和实验【摘 要】目的探讨不同交联浓度的抗癌胚抗原（CEA）单克隆抗体对液相芯片荧光检测信号的影响，明确CEA检测中最适抗体交联浓度。方法分别以不同交联浓度的标记有生物素的抗-CEA单抗与Luminex公司生产的44号荧光微球交联，交联完成后在每个反应孔中加入交联有不同浓度抗体的荧光微球各5000个，每个浓度加8孔，在每个抗体交联浓度下对应的检测孔中分别加入藻红蛋白（PE）标记的亲和素，经过15min的反应后用Luminex-100荧光检测仪检测荧光强度。结果CEA抗体的最适交联浓度为100μg／ml
体外抗原抗体反应又称血清学反应（serologic reaction），因抗体主要存在于血清中，试验时一般都采用血清标本，故名。但抗原抗体反应亦常用于细胞免疫测定，如对淋巴细胞表面分化抗原的鉴定。因此，血清学一词已被广义的抗原抗体反应所取代。 抗原与抗体在体外结合时，可因抗原的物理性状不同或参与反应的成分不同而出现各种反应，例如凝集、沉淀、补体结合及中和反应等。在此基础上进行改进，又衍生出许多快速而灵敏的抗原抗体反应，例如从凝集
抗原抗体反应（antigen-antibodyreaction）是指抗原与相应抗体之间所发生的特异性结合反应。可发生于体内（invivo），也可发生于体外（invitro）。体内反应可介导吞噬、溶菌、杀菌、中和毒素等作用；医学|教育网搜集整理体外反应则根据抗原的物理性状、抗体的类型及参与反应的介质（例如电解质、补体、固相载体等）不同，可出现凝集反应、沉淀反应、补体参与的反应及中和反应等各种不同的反应类型。 因抗体主要存在于血清中，在抗原或抗体的检测中多采用血清作试验，所以体外抗原抗体
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