Namitecan,372105-27-6

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Namitecan

CAS No. : 372105-27-6

MCE 国际站：Namitecan

产品活性：Namitecan 是一种 topoisomerase I 抑制剂，具有抗肿瘤活性。

研究领域：Cell Cycle/DNA Damage

作用靶点：Topoisomerase

In Vitro: Namitecan and cetuximab cooperate in inhibiting EGFR expression. Namitecan induces a dose-dependent decrease in EGFR expression in the different cell lines. ST1968 induces a comparable level of apoptosis in A431 and A431/TPT cells with IC₅₀ of 0.21 and 0.29 μM.

In Vivo: Namitecan (10 mg/kg) in combination with cetuximab (1 mg/mouse) induces synergistic antitumor effects in SCC models as a function of EGFR gene copy number. ST1968 (25 mg/kg) causes acceptable body weight loss and no toxic deaths. ST1968 produces a 100% complete response rate in the mice bearing the A431 tumor, and retains a relevant activity in the topotecan-resistant tumor.

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