Recombinant human DNA polymera

Purification, Separation, and Identification of the Human mtDNA Polymerase With and Without Its Accessory Subunit

The human mitochondrial genome encodes a variety of genes required for oxidative phosphorylation, and loss of these essential gene functions induces a multitude of severe metabolic disorders (1 –4 ). Mitochondrial DNA (mtDNA) is replicated

Comparative Purification Strategies for Drosophila and Human Mitochondrial DNA Replication Proteins: DNA Polymerase and Mitochondrial Single-Stranded

involving nuclear-encoded proteins that are required at the mitochondrial DNA replication fork, which often leads to human disorders and to animal lethality during development. DNA polymerase γ (pol γ), the mitochondrial replicase, and the mitochondrial

Functional Analysis of Mutant Mitochondrial DNA Polymerase Proteins Involved in Human Disease

DNA polymerase γ (pol γ) is the only DNA polymerase within the mitochondrion and is thus essential for replication and repair of mtDNA. POLG , the gene encoding the catalytic subunit of pol γ, is a major locus for a wide spectrum