SCH-23390,125941-87-9

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SCH-23390 hydrochloride

CAS No. : 125941-87-9

MCE 国际站：SCH-23390 hydrochloride

产品活性：SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) 是一种有效的选择性的多巴胺 D₁ 样受体拮抗剂，其对 D₁ 和 D₅ 受体的 K_i 分别为 0.2 nM 和 0.3 nM。SCH-23390 hydrochloride 也是一种有效的人 5-HT_2C 受体激动剂，K_i 为 9.3 nM。SCH-23390 hydrochloride 与 5-HT₂ 和 5-HT_1C 受体具有高亲和力。SCH-23390 hydrochloride 还抑制 G 蛋白偶联的内向整流钾 (GIRK) 通道，IC₅₀ 为 268 nM。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Membrane Transporter/Ion Channel

作用靶点：Dopamine Receptor  |  5-HT Receptor  |  Potassium Channel

In Vitro: SCH-23390 (1 μM) treatment reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells. SCH-23390 could reverse the Isosibiricin-mediated inhibition of the NLRP3/caspase-1 inflammasome pathway.

In Vivo: SCH-23390 can abolish generalized seizures evoked by the chemoconvulsants. SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated, such as psychosis and Parkinson's disease. Apart from the study of neurological disorders, SCH-23390 has been extensively used as a tool in the topographical determination of brain D₁ receptors in rodents, nonhuman primates, and humans.
SCH-23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3 mg/kg i.p. in the rat.
SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O₂ conditions.

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