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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
低温运输,-20℃保存
- 保质期:
6个月
- 英文名:
SUMO Protease
- 库存:
60
- 供应商:
泽叶生物
- 规格:
1000 U
SUMO蛋白酶,也称为ULP蛋白酶,是一种 具有较高活性的半胱氨酸蛋白酶。SUMO 蛋白酶以一种非常特异的方式切割蛋白, 相对于 EK 和 TEV 等蛋白酶的短小识别位 点,它特异性识别类泛素(UBL)蛋白的 三级结构-SUMO(Small Ubiquitin-Like Modifier),而不是氨基酸序列,故该蛋白 酶可以切割重组融合蛋白的SUMO。切割 的最佳温度为30℃,该酶作用温度和pH范 围(pH7-9)都比较广泛。酶切后,可通过 Ni-NTA Resin亲和纯化很容易地将SUMO 去除。本产品浓度为5 U/μL。
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文献和实验Post-translational modification by SUMO is now recognized as an important regulatory method employed by the cell to reversibly modulate the activity, stability, or localization of intracellular proteins. A dedicated enzymatic machinery
Inhibition of the SUMO Pathway by Gam1
We have previously demonstrated that Gam1, an avian adenoviral protein inhibits sumoylation. By counteracting the SUMO pathway, Gam1 has a significant impact on virus-infected cells, but in isolation the inhibitory effects of the Gam1 protein
The covalent modification of cellular factors by the small ubiquitin-like modifier (SUMO) has emerged as a key regulatory pathway for many biological processes. One recent advance in the field of SUMO modification that has provided important
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