RNF31抗体RNF31兔多抗抗体Zinc in-betwe
en-RING-finger ubiquitin-associated domain protein antibody抗体RNF31 Antibody抗体- ￥440 - 1320
- CUSABIO
- CN
- CSB-PA856927LA01HU
- 2025年07月10日
- ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant Human E3 ubiquitin-protein ligase RNF31 protein (421-700AA)
- 亚型：
IgG
- 形态：
Liquid
- 保存条件：
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性：
Polyclonal
- 标记物：
Non-conjugated
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Homo sapiens (Human)
- 目录编号：
Q96EP0
- 级别：
优
- 库存：
200
- 供应商：
武汉华美生物工程有限公司
- 宿主：
Rabbit
- 应用范围：
ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200
- 浓度：
>95%,Protein G purified
- 靶点：
RNF31
- 抗体英文名：
RNF31 Antibody
- 抗体名：
Zinc in-between-RING-finger ubiquitin-associated domain protein antibody
- 规格：
100μg/50μg/20μg
| 规格： | 100μg | 产品价格： | ￥1320.0 |
|---|---|---|---|
| 规格： | 50μg | 产品价格： | ￥880.0 |
| 规格： | 20μg | 产品价格： | ￥440.0 |
保存缓冲液
Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
功能
E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear (\'Met-1\'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验Assays for RING Family Ubiquitin Ligases
classes of E3 ligases, the HECT domain and the RING finger-containing ligases. RING finger-based ubiquitination utilizes RING-containing protein subunits, or proteins with intrinsic RING domains, to catalyze the formation of polyubiquitin chains
Domains are considered to be the building blocks of protein structures. A protein can contain a single domain or multiple domains, each one typically associated with a specific function. The combination of domains determines the function
Studies of the Ubiquitin Proteasome System
of E3 Enzymes Expressed in In Vitro Translation Systems Alternate Protocol 2: Determination of Ubiquitin Chain Variant Phenotype Basic Protocol 7: Chelation of Zinc from RING‐ and PHD‐Finger E3s Alternate Protocol 3: Inhibition of HECT Domain E
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