- ￥2024
- CUSABIO
- CN
- CSB-PA988333
- 2025年07月15日
- ELISA,WB;WB:1:500-1:3000
- Rabbit
- Human,Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Synthesized non-phosphopeptide derived from Human EPHA2 around the phosphorylation site of tyrosine 594.
- 亚型：
/
- 形态：
Liquid
- 保存条件：
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性：
Polyclonal
- 标记物：
/
- 适应物种：
Human,Mouse
- 保质期：
6个月
- 抗原来源：
Homo sapiens (Human)
- 目录编号：
P29317/P54756
- 级别：
优
- 库存：
200
- 供应商：
武汉华美生物工程有限公司
- 宿主：
Rabbit
- 应用范围：
ELISA,WB;WB:1:500-1:3000
- 浓度：
>95%,The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 靶点：
/
- 抗体英文名：
EPHA2/EPHA5 (Ab-594) Antibody
- 抗体名：
/
- 规格：
100μl
保存缓冲液
/功能
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.Lindberg R.A., Mol. Cell. Biol. 10:6316-6324(1990).
Gregory S.G., Nature 441:315-321(2006).
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