- ￥2024
- CUSABIO
- CN
- CSB-PA231077
- 2025年07月12日
- ELISA,WB,IF;WB:1:500-1:3000,IF:1:100-1:500
- Rabbit
- Human,Mouse,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Synthesized peptide derived from internal of Human COPS2.
- 亚型：
/
- 形态：
Liquid
- 保存条件：
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性：
Polyclonal
- 标记物：
/
- 适应物种：
Human,Mouse,Rat
- 保质期：
6个月
- 抗原来源：
Homo sapiens (Human)
- 目录编号：
P61201
- 级别：
优
- 库存：
200
- 供应商：
武汉华美生物工程有限公司
- 宿主：
Rabbit
- 应用范围：
ELISA,WB,IF;WB:1:500-1:3000,IF:1:100-1:500
- 浓度：
>95%,The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 靶点：
COPS2
- 抗体英文名：
COPS2 Antibody
- 抗体名：
/
- 规格：
100μl
保存缓冲液
/功能
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.Hu R.-M., Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
Lee J.W., Mol. Endocrinol. 9:243-254(1995).
Dressel U., Mol. Cell. Biol. 19:3383-3394(1999).
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COPS2抗体COPS2兔多抗抗体/抗体COPS2 Antibody抗体
￥2024
