CLDN1抗体CLDN1兔多抗抗体Senescence-as
sociated epithelial membrane protein抗体CLDN1 (Ab-210) Antibody抗体- ￥2024
- CUSABIO
- CN
- CSB-PA133727
- 2025年07月12日
- ELISA,WB;WB:1:500-1:3000
- Rabbit
- Human,Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Synthesized non-phosphopeptide derived from Human Claudin 1 around the phosphorylation site of tyrosine 210 (G-K-D-Y(p)-V).
- 亚型：
/
- 形态：
Liquid
- 保存条件：
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性：
Polyclonal
- 标记物：
/
- 适应物种：
Human,Mouse
- 保质期：
6个月
- 抗原来源：
Homo sapiens (Human)
- 目录编号：
O95832
- 级别：
优
- 库存：
200
- 供应商：
武汉华美生物工程有限公司
- 宿主：
Rabbit
- 应用范围：
ELISA,WB;WB:1:500-1:3000
- 浓度：
>95%,The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 靶点：
CLDN1
- 抗体英文名：
CLDN1 (Ab-210) Antibody
- 抗体名：
CLDN1;CLD1;SEMP1;UNQ481/PRO944;Claudin-1;Senescence-associated epithelial membrane protein
- 规格：
100μl
保存缓冲液
/功能
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (). CLDN1 acts as a coreceptor for HCV entry into hepatic cells.Swisshelm K.L., Gene 226:285-295(1999).
Halford S., Cytogenet. Cell Genet. 88:217-217(2000).
Kraemer F., Hum. Genet. 107:249-256(2000).
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文献和实验型胶原蛋白、硫酸乙酰肝素、半乳糖脑硫脂及神经节苷脂等分子结合的部位，这对基膜的构成具有重要意义。层粘连蛋白还可与上皮细胞、内皮细胞、神经细胞、肌细胞及多种肿瘤细胞相结合，促进它们粘着在基膜的Ⅳ型胶原蛋白上并铺展开，促进上皮细胞增殖、损伤神经元的存活及轴突生长。层粘连蛋白对保持细胞间的粘着和极性结构以及调节细胞分化皆有重要作用。最近证明，层粘连蛋白亦可增强由抗体或补体介导的巨噬细胞的吞噬功能，增强巨噬细胞对肿瘤细胞的杀伤作用。 （2）质膜内褶（plasma membrane
PriCells: Introduction of Isolation and Culture of Human Alveolar Epithelial Cells
;2-adrenergic receptor, insulin-like growth factor receptor-2 (IGFR-2), γ-glutamyl transferase (γ-GT), AQP-4, and VAMP-2, a membrane protein associated with caveolae. Whether or not these molecules are expressed in ATI cells exclusively
Creating Transient Cell Membrane Pores Using a Standard Inkjet Printer
), 5717-5721 (2008). 13. Apodaca, G. Endocytic Traffic in Polarized Epithelial Cells: Role of Actin and microtubule Cytoskeleton. Traffic. 2 (3), 149-159 (2001). 14. Hotulainen, P., Llano, O., Smirnov, S., Tanhuanpää, K., Faix, G., Rivera, C
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