- ￥2024
- CUSABIO
- CN
- CSB-PA884585
- 2025年07月08日
- ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100
- Rabbit
- Human,Mouse,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Synthesized non-phosphopeptide derived from Human Chk2 around the phosphorylation site of threonine 68.
- 亚型：
/
- 形态：
Liquid
- 保存条件：
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性：
Polyclonal
- 标记物：
/
- 适应物种：
Human,Mouse,Rat
- 保质期：
6个月
- 抗原来源：
Homo sapiens (Human)
- 目录编号：
O96017
- 级别：
优
- 库存：
200
- 供应商：
武汉华美生物工程有限公司
- 宿主：
Rabbit
- 应用范围：
ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100
- 浓度：
>95%,The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 靶点：
CHEK2
- 抗体英文名：
CHEK2 (Ab-68) Antibody
- 抗体名：
/
- 规格：
100μl
保存缓冲液
/功能
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells.Bhoumik A, et al. (2005) Mol Cell; 18(5): 577-87.
Gorgoulis VG, et al. (2005) Nature; 434(7035): 907-13.
Falck J, et al. (2005) Nature; 434(7033): 605-11.
Jin ZH, et al. (2005) Oncogene; 24(12): 1973-81.
Li J, et al. (2005) J Biol Chem; 280(12): 12041-50.
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文献和实验dongreyuan 有的抗体名称上面写着Ab-33，比如，β-catenin（Ab-33）antibody，请问，Ab-33是什么意思？ bettyzyj 这个抗体是非磷酸化的抗体non-phospho-antibody ，33 代表的是基因位点 dongreyuan 谢谢了 yhwangcams bettyzyj wrote
AB0系统的抗体是检验主管技师考试的内容，医学教育网搜集整理相关内容供大家参考。 天然抗体与免疫性抗体：天然抗体是在没有可觉察的抗原刺激下而产生的抗体，以IgM为主，又称完全抗体或盐水抗体；也可能是由一种无觉察的免疫刺激产生而得。免疫性抗体：有IgM、IgG、IgA，但主要是IgG.抗A和抗B可以是IgM与IgG，甚至是IgM、IgG、IgA的混合物，但主要是IgM，而0型血清中以IgG为主。
Production of Bispecif ic and Trispecific F(ab)2 and F(ab)3 Antibody Derivatives
Bispecific antibodies (BsAbs) are hybrid molecules designed to combine two antibodies with different specificities. This dual specificity has led to their application in a variety of diagnostic situations that require the crosslinking
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