产品封面图
文献支持

CHEK1抗体CHEK1兔多抗抗体/抗体CHEK1 (Ab-

317) Antibody抗体
收藏
  • ¥2024
  • CUSABIO已认证
  • CN
  • CSB-PA245196
  • 2025年07月08日
  • ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:200
  • Rabbit
  • Human,Rat
avatar
  • 企业认证

    点击 QQ 联系

    • 详细信息
    • 文献和实验
    • 技术资料
    • 免疫原

      Peptide sequence around aa.315~319 (S-S-S-Q-P) derived from Human Chk1.

    • 亚型

      /

    • 形态

      Liquid

    • 保存条件

      Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.

    • 克隆性

      Polyclonal

    • 标记物

      /

    • 适应物种

      Human,Rat

    • 保质期

      6个月

    • 抗原来源

      Homo sapiens (Human)

    • 目录编号

      O14757

    • 级别

    • 库存

      200

    • 供应商

      武汉华美生物工程有限公司

    • 宿主

      Rabbit

    • 应用范围

      ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:200

    • 浓度

      >95%,Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

    • 靶点

      CHEK1

    • 抗体英文名

      CHEK1 (Ab-317) Antibody

    • 抗体名

      /

    • 规格

      100μl


    保存缓冲液

    /

    功能

    Chek1 is a protein kinase that inhibits mitotic entry after DNA damage, required for the DNA damage checkpoint and is strongly similar to murine Chek1. Checkpoint pathways control the order and timing of cell cycle transitions and ensure that critical events, such as DNA replication and chromosome segregation, are completed with high fidelity. The mouse and human proteins share 90% sequence identity through the protein kinase domains. The sequence of the 476-amino acid human Chek1 protein is 29%, 40%, and 44% identical to those of the fission yeast Chek1, C. elegans Chek1, and Drosophila 'grapes' (Grp) proteins, respectively. Chek1 is expressed ubiquitously as an approximately 2.4-kb mRNA, with the most abundant expression in thymus, testis, small intestine, and colon. The protein has altered mobility when isolated from cells treated with ionizing radiation, indicating that Chek1 is modified in response to DNA damage. In vitro, Chek1 directly phosphorylates a regulator of CDC2 tyrosine phosphorylation, CDC25C. In response to DNA damage, Chek1 phosphorylates and inhibits CDC25C, thus preventing activation of the CDC2-Cyclin-B complex and mitotic entry

    Zhang YW, et al. (2005) Mol Cell; 19(5): 607-18.
    Bhoumik A, et al. (2005) Mol Cell; 18(5): 577-87.
    Rocha S, et al. (2005) EMBO J.
    Clarke CA, et al. (2005) Biochem J.
    Yu X, et al. (2004) Mol Cell Biol; 24(21): 9478-86.

    风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。

    图标文献和实验
    该产品被引用文献
    更多文献信息可以查看cusabio官网
    相关实验
    • 【求助】抗体名称Ab-33是什么意思?

      dongreyuan 有的抗体名称上面写着Ab-33,比如,β-catenin(Ab-33)antibody,请问,Ab-33是什么意思? bettyzyj 这个抗体是非磷酸化的抗体non-phospho-antibody ,33 代表的是基因位点 dongreyuan 谢谢了 yhwangcams bettyzyj wrote

    • AB0系统的抗体

        AB0系统的抗体是检验主管技师考试的内容,医学教育网搜集整理相关内容供大家参考。   天然抗体与免疫性抗体:天然抗体是在没有可觉察的抗原刺激下而产生的抗体,以IgM为主,又称完全抗体或盐水抗体;也可能是由一种无觉察的免疫刺激产生而得。免疫性抗体:有IgM、IgG、IgA,但主要是IgG.抗A和抗B可以是IgM与IgG,甚至是IgM、IgG、IgA的混合物,但主要是IgM,而0型血清中以IgG为主。

    • Production of Bispecif ic and Trispecific F(ab)2 and F(ab)3 Antibody Derivatives

      Bispecific antibodies (BsAbs) are hybrid molecules designed to combine two antibodies with different specificities. This dual specificity has led to their application in a variety of diagnostic situations that require the crosslinking

    图标技术资料

    暂无技术资料 索取技术资料

    同类产品报价

    产品名称
    产品价格
    公司名称
    报价日期
    ¥22
    艾美捷科技有限公司
    2025年07月12日询价
    ¥2024
    武汉华美生物工程有限公司CUSABIO®
    2025年07月16日询价
    ¥1050
    武汉菲恩生物科技有限公司
    2026年01月06日询价
    ¥2024
    武汉益普生物科技有限公司
    2025年07月11日询价
    ¥1500
    上海优宁维生物科技股份有限公司
    2025年08月21日询价
    文献支持
    CHEK1抗体CHEK1兔多抗抗体/抗体CHEK1 (Ab-317) Antibody抗体
    ¥2024