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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Peptide sequence around aa. 771~775 (P-L-Y-K-E) derived from Human Integrin b3.
- 亚型:
/
- 形态:
Liquid
- 保存条件:
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性:
Polyclonal
- 标记物:
/
- 适应物种:
Human,Mouse
- 保质期:
6个月
- 抗原来源:
Homo sapiens (Human)
- 目录编号:
P05106
- 级别:
优
- 库存:
200
- 供应商:
武汉华美生物工程有限公司
- 宿主:
Rabbit
- 应用范围:
ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:200
- 浓度:
>95%,Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- 靶点:
ITGB3
- 抗体英文名:
ITGB3 (Ab-773) Antibody
- 抗体名:
ITGB3;GP3A;Integrin beta-3;Platelet membrane glycoprotein IIIa;GPIIIa;CD antigen CD61
- 规格:
100μl
保存缓冲液
/功能
Integrin a-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin a-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins a-IIb/beta-3 and a-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin a-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin a-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.Chandhoke SK, et al.
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文献和实验人血小板膜糖蛋白IIbIIIa(GP-IIbIIIa/CD41+CD61)抗体
人血小板膜糖蛋白IIbIIIa(GP-IIbIIIa/CD41+CD61) 抗体 酶联免疫分析试剂盒使用说明书 本试剂仅供研究使用 目的:本试剂盒用于测定人血清,血浆及相关液体样本中血小板膜糖蛋白IIbIIIa(GP-IIbIIIa/CD41+CD61) 抗体 的含量。 实验原理: 本试剂盒应用双抗原夹心法测定标本中人血小板膜糖蛋白 IIbIIIa(GP-IIbIIIa/CD41+CD61) 抗体
Production of Bispecif ic and Trispecific F(ab)2 and F(ab)3 Antibody Derivatives
of two protein surfaces, for example, antigen and detecting agent in lmmunohis-tochemistry or immunoassays. More interestingly, BsAbs have been shown to have considerable therapeutic potential when used as targeting reagents to deliver pharmacological substances
【摘要】目的 构建抗CD20嵌合抗体Fab'和F(ab)2片段表达载体,并在大肠杆菌中进行高效可溶性分泌表达,比较二者的活性差异。方法 从相应的杂交瘤中提取mRNA建立抗CD20 ScFv 噬菌体显示文库,利用PCR方法从阳性克隆扩增抗CD20抗体轻链可变区基因(VL)、重链可变区基因(VH),重组到表达载体pYZF1,构建抗CD20 Fab’和抗CD20 F(ab)2达载体pYZF1cd20和pYZcpp3,并在16c9菌中高效表达。MTT法测定Fab’和F(ab)2对Raji和Daudi
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