LTA抗体LTA一抗抗体tumor necrosis fac

保存缓冲液

Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

功能

Lymphotoxin-α (LT-α), also known as TNF–β, is a member of the TNF superfamily of proteins. NK cells, T cells, B cells, and lymphoid tissue-inducer cells express LT-α. LT-α can be secreted as a soluble homotrimer or form membrane bound heterotrimers with lymphotoxin-β (LT α1β2 or LT α2β1) which can be cleaved from the cell surface by matrix metalloproteases. Soluble LT-α binds to and signals through TNFR1/TNFR2, activating the canonical NF-κB pathway. In contrast, LT α1β2 heterodimers bind to the LTβR receptor and activate the noncanonical NF-κB pathway. As a result, LT-α and TNF-α have overlapping functions. Soluble LT-α and LT α1β2 play key roles in lymphangiogenesis. The LT α1β2/LTβR axis is essential for the development of lymphoid tissue.