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- 文献和实验
- 技术资料
- 免疫原:
Synthesized peptide derived from Human JAK1 around the phosphorylation site of Y1022.
- 亚型:
IgG
- 形态:
Liquid
- 保存条件:
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性:
/
- 标记物:
Non-conjugated
- 适应物种:
Human,Mouse,Rat
- 保质期:
6个月
- 抗原来源:
Homo sapiens (Human)
- 目录编号:
P23458
- 级别:
优
- 库存:
200
- 供应商:
武汉华美生物工程有限公司
- 宿主:
Rabbit
- 应用范围:
WB, IHC, ELISA; WB:1:500-1:2000, IHC:1:100-1:300, ELISA:1:10000
- 浓度:
>95%,The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 靶点:
JAK1
- 抗体英文名:
Phospho-JAK1 (Y1022) Antibody
- 抗体名:
Tyrosine-protein kinase JAK1 antibody
- 规格:
100μg/50μg
| 规格: | 100μg | 产品价格: | ¥1320.0 |
|---|---|---|---|
| 规格: | 50μg | 产品价格: | ¥880.0 |
保存缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.功能
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文献和实验Immunoprecipitation to Determine JAK Kinase Activation in Response to Interleukins in Ovarian Cancer
In cytokine receptors, there is no consensus sequence motif for tyrosine and/or serine/threonine kinases in its intracellular domain (1 ). Cytokine receptors associate with and activate members of the Janus kinase family (JAK
1. IL-9结构 一、信号通路 IL-9 与异源二聚体受体 IL-9R 结合,并招募 Janus 激酶 JAK1 和 JAK3。磷酸化的 JAK 激酶激活 STAT1 和 STAT5 同源二聚体,以及 STAT1:STAT3 异源二聚体;这些二聚体随后转位进入细胞核并与 DNA 结合,从而调控基因表达。此外,JAK1 还能激活 IRS-1;IRS-1 进而激活依赖于 PI3-K/Akt 的抗凋亡通路,以及调控基因表达的 Ras/MAPK 信号通路。
-transduction pathways that are downstream of each of the receptors are shown. Each of these common cytokine-receptor γ-chain (γ c)-dependent cytokine s signals through a Janus activated kinase 1 (JAK1) interaction with its corresponding cytokine-specific type
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