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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Synthesized peptide derived from Human 53BP1 around the phosphorylation site of S25.
- 亚型:
IgG
- 形态:
Liquid
- 保存条件:
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性:
/
- 标记物:
Non-conjugated
- 适应物种:
Human,Mouse,Rat
- 保质期:
6个月
- 抗原来源:
Homo sapiens (Human)
- 目录编号:
Q12888
- 级别:
优
- 库存:
200
- 供应商:
武汉华美生物工程有限公司
- 宿主:
Rabbit
- 应用范围:
IHC, IF, ELISA; IHC:1:100-1:300, IF:1:200-1:1000, ELISA:1:10000
- 浓度:
>95%,The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 靶点:
TP53BP1
- 抗体英文名:
Phospho-TP53BP1 (S25) Antibody
- 抗体名:
Tumor suppressor p53-binding protein 1 antibody
- 规格:
100μg/50μg
| 规格: | 100μg | 产品价格: | ¥1320.0 |
|---|---|---|---|
| 规格: | 50μg | 产品价格: | ¥880.0 |
保存缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.功能
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文献和实验Stability and Ubiquitination of the Tumor Suppressor Protein p53
The ubiquitin-dependent proteolysis pathway constitutes a major pathway in the cell for selective protein degradation. The covalent attachment of multiple ubiquitin molecules to lysine residues of a target protein serves to signal
a central role in promoting early senescence in response to unregulated mitogenic signaling (10 ). The transactivation function of p53 is mediated through sequence-specific binding of the central domain of the protein to cisacting elements
Mutation of p53 Tumor Suppressor Gene in Hepatocellular Carcinoma
for a protein of 393 amino acids, which is expressed at relatively low levels in all tissues. p53 product is a 53-kDa phosphoprotein involved in the regulation of cell cycle, in DNA synthesis and repair, and in cell differentiation and apoptosis (see refs. 3 –
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