TP53BP1抗体TP53BP1一抗抗体Tumor supp
ressor p53-binding protein 1 antibody抗体Phospho-TP53BP1 (S6) Antibody抗体- ￥880 - 1320
- CUSABIO
- CN
- CSB-PA050307
- 2025年07月14日
- WB, IHC, ELISA; WB:1:500-1:2000, IHC:1:100-1:300, ELISA:1:5000
- Rabbit
- Human,Mouse,Rat,Monkey
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Synthesized peptide derived from Human 53BP1 around the phosphorylation site of S6.
- 亚型：
IgG
- 形态：
Liquid
- 保存条件：
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性：
/
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse,Rat,Monkey
- 保质期：
6个月
- 抗原来源：
Homo sapiens (Human)
- 目录编号：
Q12888
- 级别：
优
- 库存：
200
- 供应商：
武汉华美生物工程有限公司
- 宿主：
Rabbit
- 应用范围：
WB, IHC, ELISA; WB:1:500-1:2000, IHC:1:100-1:300, ELISA:1:5000
- 浓度：
>95%,The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 靶点：
TP53BP1
- 抗体英文名：
Phospho-TP53BP1 (S6) Antibody
- 抗体名：
Tumor suppressor p53-binding protein 1 antibody
- 规格：
100μg/50μg
| 规格： | 100μg | 产品价格： | ￥1320.0 |
|---|---|---|---|
| 规格： | 50μg | 产品价格： | ￥880.0 |
保存缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.功能
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文献和实验Stability and Ubiquitination of the Tumor Suppressor Protein p53
The ubiquitin-dependent proteolysis pathway constitutes a major pathway in the cell for selective protein degradation. The covalent attachment of multiple ubiquitin molecules to lysine residues of a target protein serves to signal
a central role in promoting early senescence in response to unregulated mitogenic signaling (10 ). The transactivation function of p53 is mediated through sequence-specific binding of the central domain of the protein to cisacting elements
Mutation of p53 Tumor Suppressor Gene in Hepatocellular Carcinoma
for a protein of 393 amino acids, which is expressed at relatively low levels in all tissues. p53 product is a 53-kDa phosphoprotein involved in the regulation of cell cycle, in DNA synthesis and repair, and in cell differentiation and apoptosis (see refs. 3 –
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