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- 2025年07月14日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
SAR 1118; SHP-606
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1025967-78-5
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥748.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥309.0 |
| 规格： | 5 mg | 产品价格： | ￥680.0 |
| 规格： | 10 mg | 产品价格： | ￥1050.0 |
| 规格： | 50 mg | 产品价格： | ￥3400.0 |
| 规格： | 100 mg | 产品价格： | ￥5450.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Lifitegrast
CAS No. : 1025967-78-5
MCE 国际站：Lifitegrast
产品活性：Lifitegrast (SAR 1118) 是一种有效的整合素 (integrin) 拮抗剂。Lifitegrast 阻断细胞间粘附分子1 (ICAM-1) 与淋巴细胞功能相关抗原 (LFA-1) 的结合，中断 T 细胞介导的炎症周期。 Lifitegrast 抑制 Jurkat T 细胞附着于 ICAM-1 的 IC50 为 2.98 nM。Lifitegrast 可用于干眼症的研究。
研究领域：Cytoskeleton
作用靶点：Integrin
In Vitro: Lifitegrast (SAR 1118) inhibits T cell-mediated inflammation by blocking the binding of two important cell surface proteins (lymphocyte function-associated antigen 1 and intercellular adhesion molecule 1), thus lessening overall inflammatory responses.
Lifitegrast strongly inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM.
In Vivo: Lifitegrast (SAR 1118), has potent anti-inflammatory activity on corneal inflammation induced by antibiotic-killed P. aeruginosa and S. aureus in the presence of a silicone hydrogel lens with the optimal application being a 1% solution applied either 2 or 3 times prior.
Lifitegrast (SAR 1118) ophthalmic drops administered thrice daily deliver therapeutic levels of Lifitegrast (SAR 1118) in the retina and can alleviate the retinal complications associated with diabetes.
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