SDMA; Symmetric dimethylargini

MCE 的所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。

SDMA

CAS No. : 30344-00-4

产品活性：SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity.

研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

In Vitro: SDMA is the structural isomer of the cardiovascular risk marker asymmetric dimethylarginine, as an endogenous marker of renal function. SDMA does not directly inhibit NOS but is a competitor of arginine transport. SDMA is primarily eliminated by renal excretion and is a promising endogenous marker of glomerular filtration rate. SDMA inhibits dose dependently the NO synthesis in intact endothelial cells, whereas it has no effect on protein expression of NOS. SDMA is involved in the inflammatory process of chronic kidney disease, activating NF-κB and resulting in enhanced expression of IL-6 and TNF-α.

In Vivo: SDMA is highly stable in serum and plasma, and the assay demonstrates excellent analytical performance. In unaffected dogs, SDMA remains unchanged whereas in affected dogs, SDMA increases during disease progression, correlating strongly with an increase in sCr and decrease in GFR. Chronic SDMA infusion leads to a significant increase of SDMA levels in mice, but the GFR did not change at 4 weeks. No histological changes are observed, particularly no effect on fibrosis or endothelias nitric oxide synthase expression. There is neither an effect of SDMA on systolic blood pressure nor on ejection fraction.

相关产品：Human Endogenous Metabolite Compound Library | Natural Product Library Plus | Natural Product Library | Metabolism/Protease Compound Library | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | 3-Methyladenine | Acetylcysteine | Hydrocortisone | Retinoic acid | Estradiol | ATP | Isoprenaline hydrochloride | Prostaglandin E2 | Melatonin | Calcitriol | Nicotinamide | Acetaminophen | Cyclopamine | Liothyronine | DHEA | Corticosterone | (R)-(-)-Phenylephrine hydrochloride | NAD+ | L-Glutathione reduced | Prostaglandin E1 | Heparan Sulfate | β-Nicotinamide mononucleotide | Progesterone | Serotonin hydrochloride | Docosahexaenoic Acid | Medroxyprogesterone acetate | 5-Aminolevulinic acid hydrochloride | Protoporphyrin IX | Hyaluronic acid | NMDA

品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
• 设有专业的实验中心和严格的质控、验证体系；
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
• 产品的生物活性多经各国客户实验验证；
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
• 专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
• 与世界各大制药公司及知名科研机构建立了长期的合作。