| CAS号 | 甲福明 盐酸盐

hydrochloride is suitable biguanide agent used in a study to investigate its role in enhancing the secretions of plasma active glucagon-like peptide-1 (GLP-1) levels.[4] It may be used in the synthesis of the following:
• bis(1,1-dimethylbiguanido)copper(II) octahydrate[1]
• bis(1,1-dimethylbiguanido)nickel(II)[2]
• 1,1-dimethylbiguanidium tetrabromothallate(III)[3]
General description1,1-Dimethylbiguanide hydrochloride (metformin) is a strong base. It forms well defined salts and possessing excellent coordination capacity with transition metals, forming highly colored bidentate chelate complexes.[1] Metformin (MET) exists in various forms: diprotonated (H2MET)2+ in strong acidic solution, monoprotonated (HMET)+ in weak acid, MET in neutral and deprotonated (MET)-in strong alkali solution.[2] It is an oral antidiabetic drug. Pharmacokinetics of metformin has been studied.[6] Determination of metformin in human plasma has been described by simple HPLC-UV method.[5] Metformin is reported to increase plasma active glucagon-like peptide-1 (GLP-1) in humans.[4]